Stimulation of ventilation by normobaric hyperoxia in exercising dogs

Philippe Haouzi, E. M. Allioui, J. P. Gille, Y. Bedez, B. Tousseul, B. Chalon

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

In order to describe the factors which, during hyperoxic exercise, can counteract the chemoreceptor-mediated inhibition of ventilation by O2, minute ventilation (V̇) and the pulmonary gas exchange were studied breath-by-breath in four dogs running on a treadmill (5 km h-1) for 10 min during and following exposure to O2 of different durations. We found that a brief inhalation of O2 applied during the steady state of the V̇ response provoked a reduction in V̇ by 6.5±0.9 l min-1 whereas hyperoxia applied 2 min before the onset of exercise and maintained for 2.5 min during the running tests had a significantly weaker effect on V̇ (-1.8±0.2 l min-1, P<0.05). The rise in pulmonary CO2 output (V̇(CO2)) during the prolonged O2 exposure was less than in normoxic exercise leading to a deficit of CO2 eliminated by the lungs of 181 ml. The return to air breathing provoked a rise in V̇, which reached within 73 s a much higher level than the control tests (22.9 ± 3.6 vs. 19.5 ± 2.21 min-1, P<0.05); V̇ then subsided to control levels with a long exponential decline. The CO2 deficit during O2 breathing, was fully compensated after recovery in air within 6 min. No stimulatory effect on ventilation was observed at rest at the cessation of a similar exposure to O2 despite a higher end-tidal P(CO2) (+4 ± 1 mmHg) than in exercise. In conclusion, the stimulatory effect of O2 during exercise can be clearly revealed after recovery in air and seems to operate through a more complex mechanism than that thought to be involved at rest. We propose that the changes in CO2 stores in the exercising muscles could contribute to O2-induced stimulation during exercise, possibly through stimulation of muscle afferents responding to local circulatory changes. Finally, the observation that during continuous dopamine (DA) infusion (5 μg kg-1 min-1) the V(E) response to recovery in air was only a slow decrease, suggests that the arterial chemoreceptors potentiate O2-induced hyperventilation, or that the vascular actions of DA counteract part of the effects provoked by CO2 accumulation in the exercising muscles.

Original languageEnglish (US)
Pages (from-to)829-838
Number of pages10
JournalExperimental Physiology
Volume85
Issue number6
DOIs
StatePublished - Jan 1 2000

All Science Journal Classification (ASJC) codes

  • Physiology
  • Nutrition and Dietetics
  • Physiology (medical)

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