Stimuli-Responsive Polymer Film that Autonomously Translates a Molecular Detection Event into a Macroscopic Change in Its Optical Properties via a Continuous, Thiol-Mediated Self-Propagating Reaction

Hemakesh Mohapatra, Hyungwoo Kim, Scott T. Phillips

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

This Communication describes a chemically responsive polymer film that is capable of detecting low levels of a specific applied molecular signal (thiol) and subsequently initiating a self-propagating reaction within the material that converts the nonfluorescent film into a globally fluorescent material. We illustrate that the intensity of the resulting fluorescent material is independent of the quantity of the applied thiol, whereas the rate to reach the maximum level of signal is directly proportional to the quantity of the signal. In contrast, a control film, which lacks functionality for mediating the self-propagating reaction, provides a maximum change in fluorescence that is directly proportional to the quantity of the applied thiol. This level of nonamplified signal is 78% lower in intensity (when initiated with 100 μM of applied thiol) than is achieved when the material contains functionality that supports the self-powered, self-propagating amplification reaction.

Original languageEnglish (US)
Pages (from-to)12498-12501
Number of pages4
JournalJournal of the American Chemical Society
Volume137
Issue number39
DOIs
StatePublished - Oct 7 2015

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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