Stochastic sensors inspired by biology

Hagan Bayley, Paul S. Cremer

Research output: Contribution to journalReview article

893 Scopus citations

Abstract

Sensory systems use a variety of membrane-bound receptors, including responsive ion channels, to discriminate between a multitude of stimuli. Here we describe how engineered membrane pores can be used to make rapid and sensitive biosensors with potential applications that range from the detection of biological warfare agents to pharmaceutical screening. Notably, use of the engineered pores in stochastic sensing, a single-molecule detection technology, reveals the identity of an analyte as well as its concentration.

Original languageEnglish (US)
Pages (from-to)226-230
Number of pages5
JournalNature
Volume413
Issue number6852
DOIs
StatePublished - Sep 13 2001

All Science Journal Classification (ASJC) codes

  • General

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