Strain-dependent performance in nicotine-induced conditioned place preference

Munir Gunes Kutlu, Leonardo A. Ortega, Thomas J. Gould

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Nicotine addiction is most likely a result of a combination of factors including the rewarding effects of the drug; these effects, however, might be influenced by genetic background. Using a conditioned place preference (CPP) paradigm and 8 inbred mouse strains, we conducted an initial examination of the role of genetic background in the rewarding effects of nicotine. Following habituation and initial place preference test, inbred strains (A/J, BALB/cByJ, C3H/HeJ, C57BL/6J, CBA/J, DBA/1J, DBA/2J, and 129/SvEv) were trained and tested in CPP for nicotine (0.35 mg/kg). Although several strains (C57BL/6J, CBA/J, and 129/SvEv) showed nicotine-induced CPP, 1 strain (DBA/1J) showed conditioned place aversion (CPA), and other strains (A/J, BALB/cByJ, C3H/HeJ, and DBA/2J) did not show CPP. Overall, these results indicate that nicotine's rewarding effects tested in CPP are differentially affected by the genetic background, and this trait has a relatively high heritability (42%-57%). This initial investigation lays the foundation for future studies examining the genetic substrates of nicotine reward.

Original languageEnglish (US)
Pages (from-to)37-41
Number of pages5
JournalBehavioral Neuroscience
Volume129
Issue number1
DOIs
StatePublished - Jan 1 2015

Fingerprint

Nicotine
Inbred Strains Mice
Reward
Pharmaceutical Preparations
Genetic Background

All Science Journal Classification (ASJC) codes

  • Behavioral Neuroscience

Cite this

Kutlu, Munir Gunes ; Ortega, Leonardo A. ; Gould, Thomas J. / Strain-dependent performance in nicotine-induced conditioned place preference. In: Behavioral Neuroscience. 2015 ; Vol. 129, No. 1. pp. 37-41.
@article{6ca041645274446baa12188bf5eb44ca,
title = "Strain-dependent performance in nicotine-induced conditioned place preference",
abstract = "Nicotine addiction is most likely a result of a combination of factors including the rewarding effects of the drug; these effects, however, might be influenced by genetic background. Using a conditioned place preference (CPP) paradigm and 8 inbred mouse strains, we conducted an initial examination of the role of genetic background in the rewarding effects of nicotine. Following habituation and initial place preference test, inbred strains (A/J, BALB/cByJ, C3H/HeJ, C57BL/6J, CBA/J, DBA/1J, DBA/2J, and 129/SvEv) were trained and tested in CPP for nicotine (0.35 mg/kg). Although several strains (C57BL/6J, CBA/J, and 129/SvEv) showed nicotine-induced CPP, 1 strain (DBA/1J) showed conditioned place aversion (CPA), and other strains (A/J, BALB/cByJ, C3H/HeJ, and DBA/2J) did not show CPP. Overall, these results indicate that nicotine's rewarding effects tested in CPP are differentially affected by the genetic background, and this trait has a relatively high heritability (42{\%}-57{\%}). This initial investigation lays the foundation for future studies examining the genetic substrates of nicotine reward.",
author = "Kutlu, {Munir Gunes} and Ortega, {Leonardo A.} and Gould, {Thomas J.}",
year = "2015",
month = "1",
day = "1",
doi = "10.1037/bne0000029",
language = "English (US)",
volume = "129",
pages = "37--41",
journal = "Behavioral Neuroscience",
issn = "0735-7044",
publisher = "American Psychological Association Inc.",
number = "1",

}

Strain-dependent performance in nicotine-induced conditioned place preference. / Kutlu, Munir Gunes; Ortega, Leonardo A.; Gould, Thomas J.

In: Behavioral Neuroscience, Vol. 129, No. 1, 01.01.2015, p. 37-41.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Strain-dependent performance in nicotine-induced conditioned place preference

AU - Kutlu, Munir Gunes

AU - Ortega, Leonardo A.

AU - Gould, Thomas J.

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Nicotine addiction is most likely a result of a combination of factors including the rewarding effects of the drug; these effects, however, might be influenced by genetic background. Using a conditioned place preference (CPP) paradigm and 8 inbred mouse strains, we conducted an initial examination of the role of genetic background in the rewarding effects of nicotine. Following habituation and initial place preference test, inbred strains (A/J, BALB/cByJ, C3H/HeJ, C57BL/6J, CBA/J, DBA/1J, DBA/2J, and 129/SvEv) were trained and tested in CPP for nicotine (0.35 mg/kg). Although several strains (C57BL/6J, CBA/J, and 129/SvEv) showed nicotine-induced CPP, 1 strain (DBA/1J) showed conditioned place aversion (CPA), and other strains (A/J, BALB/cByJ, C3H/HeJ, and DBA/2J) did not show CPP. Overall, these results indicate that nicotine's rewarding effects tested in CPP are differentially affected by the genetic background, and this trait has a relatively high heritability (42%-57%). This initial investigation lays the foundation for future studies examining the genetic substrates of nicotine reward.

AB - Nicotine addiction is most likely a result of a combination of factors including the rewarding effects of the drug; these effects, however, might be influenced by genetic background. Using a conditioned place preference (CPP) paradigm and 8 inbred mouse strains, we conducted an initial examination of the role of genetic background in the rewarding effects of nicotine. Following habituation and initial place preference test, inbred strains (A/J, BALB/cByJ, C3H/HeJ, C57BL/6J, CBA/J, DBA/1J, DBA/2J, and 129/SvEv) were trained and tested in CPP for nicotine (0.35 mg/kg). Although several strains (C57BL/6J, CBA/J, and 129/SvEv) showed nicotine-induced CPP, 1 strain (DBA/1J) showed conditioned place aversion (CPA), and other strains (A/J, BALB/cByJ, C3H/HeJ, and DBA/2J) did not show CPP. Overall, these results indicate that nicotine's rewarding effects tested in CPP are differentially affected by the genetic background, and this trait has a relatively high heritability (42%-57%). This initial investigation lays the foundation for future studies examining the genetic substrates of nicotine reward.

UR - http://www.scopus.com/inward/record.url?scp=84930374278&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84930374278&partnerID=8YFLogxK

U2 - 10.1037/bne0000029

DO - 10.1037/bne0000029

M3 - Article

C2 - 25546366

AN - SCOPUS:84930374278

VL - 129

SP - 37

EP - 41

JO - Behavioral Neuroscience

JF - Behavioral Neuroscience

SN - 0735-7044

IS - 1

ER -