Strategies to elucidate the mechanism of excessive theca cell androgen production in PCOS

Jerome F. Strauss, Jennifer R. Wood, Lane K. Christenson, Jan M. McAllister

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Polycystic ovary syndrome (PCOS) is characterized by increased ovarian androgen production. We have developed a strategy to identify differentially transcribed genes in PCOS theca cells. Using long-term cultures of normal and PCOS theca cells, we are characterizing the complete repertoire of differentially transcribed genes, the common transcription factor mediators, and the signal transduction cascade(s) that are abnormal in PCOS theca cells. The latter will be interrogated for mutations/genetic variants linked to PCOS.

Original languageEnglish (US)
Pages (from-to)183-188
Number of pages6
JournalMolecular and Cellular Endocrinology
Volume186
Issue number2
DOIs
StatePublished - Jan 25 2002

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Endocrinology

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