Stratifying risk of biliary complications in adult living donor liver transplantation by magnetic resonance cholangiography

Randeep Kashyap, Adel Bozorgzadeh, Peter Abt, Georgios Tsoulfas, Manoj Maloo, Rajeev Sharma, Siddharth Patel, David Dombroski, Parvez Mantry, Saman Safadjou, Ashok Jain, Mark Orloff

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

BACKGROUND.: Accurate preoperative assessment of biliary anatomy in live donor hepatectomy may be helpful to assess the suitability of a graft and to stratify risk of biliary complications. METHODS.: A retrospective review of existing data among donor and recipients of 36 living donor transplants was performed to assess role of preoperative magnetic resonance cholangiography (MRC) for defining biliary anatomy and to stratify risk of biliary complications. RESULTS.: Thirty-six living liver donors underwent MRC, and subsequently right lobectomy. Intraoperative cholangiography and biliary exploration revealed that 24 donors (66.6%) had conventional and 12 (33.3%) had aberrant biliary anatomy. Intraoperative cholangiography demonstrated a strong correlation with MRC (P=0.001) and intraoperative findings (P=0.001). MRC had specificity and positive predictive value of 100%. The risk of developing biliary complication was 5.9 times higher if the biliary anatomy was of any type other than A (P=0.03, CI 1.06-32.9) after controlling for donor age, recipient age, and type of anastomosis. CONCLUSION.: MRC reliably identified variant biliary anatomy. The preoperative MRC demonstrated congruence with the intraoperative cholangiogram and with the intraoperative findings. MRC is helpful in predicting risk of biliary complications in recipients, and identifies donors who would otherwise be excluded intraoperatively by cholangiography, thus limiting the risk of an unnecessary operation. & copy; 2008 by Lippincott Williams & Wilkins.

Original languageEnglish (US)
Pages (from-to)1569-1572
Number of pages4
JournalTransplantation
Volume85
Issue number11
DOIs
StatePublished - Jun 15 2008

All Science Journal Classification (ASJC) codes

  • Transplantation

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