Streamline based design of a mems device for continuous blood cell separation

Siyang Zheng, Yu Chong Tai

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

We report a new MEMS device for continuous separation of particles based on size. Unlike previous passive fluidic devices for particle separation, fluidic streamline design based on local geometry and fluidic resistance of side channels are used. The filtering effect is achieved not by physical device boundaries, but by the collection zones established by fluidic field. The separation region of the device has a small footprint of 1.5mm by 0.8mm for separation of particles in micron range. The particles are automatically collected in different exit channels after they are separated, which facilitate further sensing and processing. Like crossflow filters, particles are separated perpendicular to flow direction. The minimal feature size of the device is designed to be larger than the diameter of the largest particles, so clogging can be minimized. Solvent exchange can be accomplished for larger particles. We demonstrate separation of 5m and 10m polystyrene beads, as well as erythrocytes and leukocytes of human blood with better than 96% efficiency.

Original languageEnglish (US)
Title of host publication2006 Solid-State Sensors, Actuators, and Microsystems Workshop, Hilton Head 2006
EditorsLeland Spangler, Thomas W. Kenny
PublisherTransducer Research Foundation
Pages140-143
Number of pages4
ISBN (Electronic)0964002469, 9780964002463
StatePublished - Jan 1 2006
Event13th Solid-State Sensors, Actuators, and Microsystems Workshop, Hilton Head 2006 - Hilton Head Island, United States
Duration: Jun 4 2006Jun 8 2006

Publication series

NameTechnical Digest - Solid-State Sensors, Actuators, and Microsystems Workshop

Conference

Conference13th Solid-State Sensors, Actuators, and Microsystems Workshop, Hilton Head 2006
CountryUnited States
CityHilton Head Island
Period6/4/066/8/06

Fingerprint

Blood
Cells
Fluidics
Fluidic devices
MEMS
Polystyrenes
Geometry
Processing

All Science Journal Classification (ASJC) codes

  • Control and Systems Engineering
  • Electrical and Electronic Engineering
  • Hardware and Architecture

Cite this

Zheng, S., & Tai, Y. C. (2006). Streamline based design of a mems device for continuous blood cell separation. In L. Spangler, & T. W. Kenny (Eds.), 2006 Solid-State Sensors, Actuators, and Microsystems Workshop, Hilton Head 2006 (pp. 140-143). (Technical Digest - Solid-State Sensors, Actuators, and Microsystems Workshop). Transducer Research Foundation.
Zheng, Siyang ; Tai, Yu Chong. / Streamline based design of a mems device for continuous blood cell separation. 2006 Solid-State Sensors, Actuators, and Microsystems Workshop, Hilton Head 2006. editor / Leland Spangler ; Thomas W. Kenny. Transducer Research Foundation, 2006. pp. 140-143 (Technical Digest - Solid-State Sensors, Actuators, and Microsystems Workshop).
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Zheng, S & Tai, YC 2006, Streamline based design of a mems device for continuous blood cell separation. in L Spangler & TW Kenny (eds), 2006 Solid-State Sensors, Actuators, and Microsystems Workshop, Hilton Head 2006. Technical Digest - Solid-State Sensors, Actuators, and Microsystems Workshop, Transducer Research Foundation, pp. 140-143, 13th Solid-State Sensors, Actuators, and Microsystems Workshop, Hilton Head 2006, Hilton Head Island, United States, 6/4/06.

Streamline based design of a mems device for continuous blood cell separation. / Zheng, Siyang; Tai, Yu Chong.

2006 Solid-State Sensors, Actuators, and Microsystems Workshop, Hilton Head 2006. ed. / Leland Spangler; Thomas W. Kenny. Transducer Research Foundation, 2006. p. 140-143 (Technical Digest - Solid-State Sensors, Actuators, and Microsystems Workshop).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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Zheng S, Tai YC. Streamline based design of a mems device for continuous blood cell separation. In Spangler L, Kenny TW, editors, 2006 Solid-State Sensors, Actuators, and Microsystems Workshop, Hilton Head 2006. Transducer Research Foundation. 2006. p. 140-143. (Technical Digest - Solid-State Sensors, Actuators, and Microsystems Workshop).