Stress and wound healing

Lisa M. Christian, Jennifer E. Graham, David A. Padgett, Ronald Glaser, Janice K. Kiecolt-Glaser

Research output: Contribution to journalReview article

131 Citations (Scopus)

Abstract

Over the past decade it has become clear that stress can significantly slow wound healing: stressors ranging in magnitude and duration impair healing in humans and animals. For example, in humans, the chronic stress of caregiving as well as the relatively brief stress of academic examinations impedes healing. Similarly, restraint stress slows healing in mice. The interactive effects of glucocorticoids (e.g. cortisol and corticosterone) and proinflammatory cytokines [e.g. interleukin-1β (IL-1β), IL-1α, IL-6, IL-8, and tumor necrosis factor-α] are primary physiological mechanisms underlying the stress and healing connection. The effects of stress on healing have important implications in the context of surgery and naturally occurring wounds, particularly among at-risk and chronically ill populations. In research with clinical populations, greater attention to measurement of health behaviors is needed to better separate behavioral versus direct physiological effects of stress on healing. Recent evidence suggests that interventions designed to reduce stress and its concomitants (e.g., exercise, social support) can prevent stress-induced impairments in healing. Moreover, specific physiological mechanisms are associated with certain types of interventions. In future research, an increased focus on mechanisms will help to more clearly elucidate pathways linking stress and healing processes.

Original languageEnglish (US)
Pages (from-to)337-346
Number of pages10
JournalNeuroImmunoModulation
Volume13
Issue number5-6
DOIs
StatePublished - Aug 1 2007

Fingerprint

Wound Healing
Interleukin-1
Health Behavior
Corticosterone
Interleukin-8
Social Support
Glucocorticoids
Population
Hydrocortisone
Interleukin-6
Chronic Disease
Tumor Necrosis Factor-alpha
Cytokines
Wounds and Injuries
Research

All Science Journal Classification (ASJC) codes

  • Immunology
  • Endocrinology
  • Neurology
  • Endocrine and Autonomic Systems

Cite this

Christian, L. M., Graham, J. E., Padgett, D. A., Glaser, R., & Kiecolt-Glaser, J. K. (2007). Stress and wound healing. NeuroImmunoModulation, 13(5-6), 337-346. https://doi.org/10.1159/000104862
Christian, Lisa M. ; Graham, Jennifer E. ; Padgett, David A. ; Glaser, Ronald ; Kiecolt-Glaser, Janice K. / Stress and wound healing. In: NeuroImmunoModulation. 2007 ; Vol. 13, No. 5-6. pp. 337-346.
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Christian, LM, Graham, JE, Padgett, DA, Glaser, R & Kiecolt-Glaser, JK 2007, 'Stress and wound healing', NeuroImmunoModulation, vol. 13, no. 5-6, pp. 337-346. https://doi.org/10.1159/000104862

Stress and wound healing. / Christian, Lisa M.; Graham, Jennifer E.; Padgett, David A.; Glaser, Ronald; Kiecolt-Glaser, Janice K.

In: NeuroImmunoModulation, Vol. 13, No. 5-6, 01.08.2007, p. 337-346.

Research output: Contribution to journalReview article

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Christian LM, Graham JE, Padgett DA, Glaser R, Kiecolt-Glaser JK. Stress and wound healing. NeuroImmunoModulation. 2007 Aug 1;13(5-6):337-346. https://doi.org/10.1159/000104862