Stress erythropoiesis model systems

Laura F. Bennett, Chang Liao, Robert F. Paulson

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Scopus citations

Abstract

Bone marrow steady-state erythropoiesis maintains erythroid homeostasis throughout life. This process constantly generates new erythrocytes to replace the senescent erythrocytes that are removed by macrophages in the spleen. In contrast, anemic or hypoxic stress induces a physiological response designed to increase oxygen delivery to the tissues. Stress erythropoiesis is a key component of this response. It is best understood in mice where it is extramedullary occurring in the adult spleen and liver and in the fetal liver during development. Stress erythropoiesis utilizes progenitor cells and signals that are distinct from bone marrow steady-state erythropoiesis. Because of that observation many genes may play a role in stress erythropoiesis despite having no effect on steady-state erythropoiesis. In this chapter, we will discuss in vivo and in vitro techniques to study stress erythropoiesis in mice and how the in vitro culture system can be extended to study human stress erythropoiesis.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages91-102
Number of pages12
DOIs
StatePublished - 2018

Publication series

NameMethods in Molecular Biology
Volume1698
ISSN (Print)1064-3745

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics

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    Bennett, L. F., Liao, C., & Paulson, R. F. (2018). Stress erythropoiesis model systems. In Methods in Molecular Biology (pp. 91-102). (Methods in Molecular Biology; Vol. 1698). Humana Press Inc.. https://doi.org/10.1007/978-1-4939-7428-3_5