Stress resistant human embryonic stem cells as a potential source for the identification of novel cancer stem cell markers

Shaker A. Mousa, Thangirala Sudha, Evgeny Dyskin, Usawadee Dier, Christine Gallati, Christine Hanko, Sridar V. Chittur, Abdelhadi Rebbaa

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Cancer stem cells are known for their inherent resistance to therapy. Here we investigated whether normal stem cells with acquired resistance to stress can be used to identify novel markers of cancer stem cells. For this, we generated a human embryonic stem cell line resistant to Trichostatin A and analyzed changes in its gene expression. The resistant cells over-expressed various genes associated with tumor aggressiveness, many of which are also expressed in the CD133+ glioma cancer stem cells. These findings suggest that stress-resistant stem cells generated in vitro may be useful for the discovery of novel markers of cancer stem cells.

Original languageEnglish (US)
Pages (from-to)208-216
Number of pages9
JournalCancer Letters
Volume289
Issue number2
DOIs
StatePublished - Mar 28 2010

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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