Striatal extracellular dopamine levels are not increased by hyperglycemic exacerbation of ischemic brain damage in rats

W. Andrew Kofke, Robert H. Garman, Richard Stiller, Marie Rose, Janine Janosky

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2 Scopus citations

Abstract

We tested the hypothesis that hyperglycemic exacerbation of incomplete forebrain ischemia is mediated by increased extracellular dopamine levels. Normoglycemic and hyperglycemic Sprgue-Dawley rats (eight each) with previously placed coaxial striatal microdialysis probes underwent 12 min of forebrain carotid artery occlusion and trimethaphan-induced hypotension. Microdialysis was performed before, during and for 6 h after ischemia, then perfusion-fixation was performed. Hyperglycemic rats had more severe postischemic damage in the caudate-putamen, neocortex, and hippocampus. Extracellular striatal dopamine levels were increased by ischemia, but were unaffected by hyperglycemia. These data show that hyperglycemic exacerbation of ischemic striatal damage does not depend on elevated extracellular dopamine levels.

Original languageEnglish (US)
Pages (from-to)171-177
Number of pages7
JournalBrain research
Volume633
Issue number1-2
DOIs
StatePublished - Jan 7 1994

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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