Striatal responses to negative monetary outcomes differ between temperamentally inhibited and non-inhibited adolescents

Sarah M. Helfinstein, Brenda Benson, Koraly Elisa Perez-Edgar, Yair Bar-Haim, Allison Detloff, Daniel S. Pine, Nathan A. Fox, Monique Ernst

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

The present study compared blood oxygen level dependent (BOLD) response in behaviorally inhibited and behaviorally non-inhibited adolescents to positive and negative feedback following their choice in a reward task. Previous data in these same subjects showed enhanced activation in striatal areas in behaviorally inhibited subjects to cues predicting gain or a loss. However, no analyses had examined responses following actual gains or losses. Relative to non-inhibited subjects, behaviorally inhibited subjects in the current study showed enhanced caudate response to negative but not positive feedback, indicating that striatal sensitivity to feedback may be specific to aversive information. In addition, compared to non-inhibited subjects, behaviorally inhibited subjects exhibited reduced differentiation between positive and negative feedback in ventromedial prefrontal cortex (vmPFC). This suggests a perturbed ability to encode reward value.

Original languageEnglish (US)
Pages (from-to)479-485
Number of pages7
JournalNeuropsychologia
Volume49
Issue number3
DOIs
StatePublished - Feb 1 2011

Fingerprint

Corpus Striatum
Reward
Aptitude
Prefrontal Cortex
Cues
Oxygen

All Science Journal Classification (ASJC) codes

  • Experimental and Cognitive Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience

Cite this

Helfinstein, Sarah M. ; Benson, Brenda ; Perez-Edgar, Koraly Elisa ; Bar-Haim, Yair ; Detloff, Allison ; Pine, Daniel S. ; Fox, Nathan A. ; Ernst, Monique. / Striatal responses to negative monetary outcomes differ between temperamentally inhibited and non-inhibited adolescents. In: Neuropsychologia. 2011 ; Vol. 49, No. 3. pp. 479-485.
@article{1f2fc53e2eed4dc396f4ab138cc893f9,
title = "Striatal responses to negative monetary outcomes differ between temperamentally inhibited and non-inhibited adolescents",
abstract = "The present study compared blood oxygen level dependent (BOLD) response in behaviorally inhibited and behaviorally non-inhibited adolescents to positive and negative feedback following their choice in a reward task. Previous data in these same subjects showed enhanced activation in striatal areas in behaviorally inhibited subjects to cues predicting gain or a loss. However, no analyses had examined responses following actual gains or losses. Relative to non-inhibited subjects, behaviorally inhibited subjects in the current study showed enhanced caudate response to negative but not positive feedback, indicating that striatal sensitivity to feedback may be specific to aversive information. In addition, compared to non-inhibited subjects, behaviorally inhibited subjects exhibited reduced differentiation between positive and negative feedback in ventromedial prefrontal cortex (vmPFC). This suggests a perturbed ability to encode reward value.",
author = "Helfinstein, {Sarah M.} and Brenda Benson and Perez-Edgar, {Koraly Elisa} and Yair Bar-Haim and Allison Detloff and Pine, {Daniel S.} and Fox, {Nathan A.} and Monique Ernst",
year = "2011",
month = "2",
day = "1",
doi = "10.1016/j.neuropsychologia.2010.12.015",
language = "English (US)",
volume = "49",
pages = "479--485",
journal = "Neuropsychologia",
issn = "0028-3932",
publisher = "Elsevier Limited",
number = "3",

}

Striatal responses to negative monetary outcomes differ between temperamentally inhibited and non-inhibited adolescents. / Helfinstein, Sarah M.; Benson, Brenda; Perez-Edgar, Koraly Elisa; Bar-Haim, Yair; Detloff, Allison; Pine, Daniel S.; Fox, Nathan A.; Ernst, Monique.

In: Neuropsychologia, Vol. 49, No. 3, 01.02.2011, p. 479-485.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Striatal responses to negative monetary outcomes differ between temperamentally inhibited and non-inhibited adolescents

AU - Helfinstein, Sarah M.

AU - Benson, Brenda

AU - Perez-Edgar, Koraly Elisa

AU - Bar-Haim, Yair

AU - Detloff, Allison

AU - Pine, Daniel S.

AU - Fox, Nathan A.

AU - Ernst, Monique

PY - 2011/2/1

Y1 - 2011/2/1

N2 - The present study compared blood oxygen level dependent (BOLD) response in behaviorally inhibited and behaviorally non-inhibited adolescents to positive and negative feedback following their choice in a reward task. Previous data in these same subjects showed enhanced activation in striatal areas in behaviorally inhibited subjects to cues predicting gain or a loss. However, no analyses had examined responses following actual gains or losses. Relative to non-inhibited subjects, behaviorally inhibited subjects in the current study showed enhanced caudate response to negative but not positive feedback, indicating that striatal sensitivity to feedback may be specific to aversive information. In addition, compared to non-inhibited subjects, behaviorally inhibited subjects exhibited reduced differentiation between positive and negative feedback in ventromedial prefrontal cortex (vmPFC). This suggests a perturbed ability to encode reward value.

AB - The present study compared blood oxygen level dependent (BOLD) response in behaviorally inhibited and behaviorally non-inhibited adolescents to positive and negative feedback following their choice in a reward task. Previous data in these same subjects showed enhanced activation in striatal areas in behaviorally inhibited subjects to cues predicting gain or a loss. However, no analyses had examined responses following actual gains or losses. Relative to non-inhibited subjects, behaviorally inhibited subjects in the current study showed enhanced caudate response to negative but not positive feedback, indicating that striatal sensitivity to feedback may be specific to aversive information. In addition, compared to non-inhibited subjects, behaviorally inhibited subjects exhibited reduced differentiation between positive and negative feedback in ventromedial prefrontal cortex (vmPFC). This suggests a perturbed ability to encode reward value.

UR - http://www.scopus.com/inward/record.url?scp=79551500383&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79551500383&partnerID=8YFLogxK

U2 - 10.1016/j.neuropsychologia.2010.12.015

DO - 10.1016/j.neuropsychologia.2010.12.015

M3 - Article

C2 - 21167189

AN - SCOPUS:79551500383

VL - 49

SP - 479

EP - 485

JO - Neuropsychologia

JF - Neuropsychologia

SN - 0028-3932

IS - 3

ER -