Striatal volume changes in the rat following long-term administration of typical and atypical antipsychotic drugs

Candace Andersson, Robert M. Hamer, Cindy P. Lawler, Richard Mailman, Jeffrey A. Lieberman

Research output: Contribution to journalArticle

87 Citations (Scopus)

Abstract

Striatal enlargement has been consistently reported in schizophrenics receiving chronic neuroleptic treatment although the results following atypical antipsychotic treatment have been equivocal. In order to disentangle patient illness from a possible drug effect on brain structure, young adult rats were administered either haloperidol, risperidone, clozapine, olanzapine, or vehicle daily for four or eight months via drinking water. Significant increases in caudate-putamen volumes were seen in animals receiving either haloperidol or clozapine when compared with control animals following eight months of drug administration. Conversely, olanzapine-treated animals showed significant decreases in caudate-putamen volumes when compared with control animals after eight months of drug. Thus, converging evidence indicates that the neuroplastic response of the striatum following neuroleptic exposure causes volumetric increases, whereas atypical antipsychotics affect the basal ganglia differentially. The current data suggests that such differential responses may be due to both the pharmacological properties and the relative doses of the atypical agents.

Original languageEnglish (US)
Pages (from-to)143-151
Number of pages9
JournalNeuropsychopharmacology
Volume27
Issue number2
DOIs
StatePublished - Jul 6 2002

Fingerprint

Corpus Striatum
olanzapine
Antipsychotic Agents
Clozapine
Putamen
Haloperidol
Pharmaceutical Preparations
Risperidone
Basal Ganglia
Drinking Water
Young Adult
Pharmacology
Brain
Therapeutics

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Psychiatry and Mental health

Cite this

Andersson, Candace ; Hamer, Robert M. ; Lawler, Cindy P. ; Mailman, Richard ; Lieberman, Jeffrey A. / Striatal volume changes in the rat following long-term administration of typical and atypical antipsychotic drugs. In: Neuropsychopharmacology. 2002 ; Vol. 27, No. 2. pp. 143-151.
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Striatal volume changes in the rat following long-term administration of typical and atypical antipsychotic drugs. / Andersson, Candace; Hamer, Robert M.; Lawler, Cindy P.; Mailman, Richard; Lieberman, Jeffrey A.

In: Neuropsychopharmacology, Vol. 27, No. 2, 06.07.2002, p. 143-151.

Research output: Contribution to journalArticle

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