Strontium administration in young chickens improves bone volume and architecture but does not enhance bone structural and material strength

M. Shahnazari, D. H. Lang, G. J. Fosmire, Neil Sharkey, A. D. Mitchell, R. M. Leach

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Genetic selection for rapid body growth in broiler chickens has resulted in adverse effects on the skeletal system exemplified by a higher rate of cortical fractures in leg bones. Strontium (Sr) has been reported to have beneficial effects on bone formation and strength. We supplemented the diet of 300-day-old chicks with increasing dosages of Sr (0%, 0.12%, or 0.24%) to study the capacity of the element to improve bone quality and mechanical integrity. Treatment with Sr increased cortical bone volume and reduced bone porosity as measured by micro-computed tomography. The higher level of Sr significantly reduced bone Ca content (34.7%) relative to controls (37.2%), suggesting that Sr replaced some of the Ca in bone. Material properties determined by the three-point bending test showed that bone in the Sr-treated groups withstood greater deformation prior to fracture. Load to failure and ultimate stress were similar across groups. Our results indicate that Sr treatment in rapidly growing chickens induced positive effects on bone volume but did not improve the breaking strength of long bones.

Original languageEnglish (US)
Pages (from-to)160-166
Number of pages7
JournalCalcified Tissue International
Volume80
Issue number3
DOIs
StatePublished - Mar 1 2007

Fingerprint

Strontium
Chickens
Bone and Bones
Leg Bones
Genetic Selection
Porosity
Osteogenesis
Tomography
Diet
Growth

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Orthopedics and Sports Medicine
  • Endocrinology

Cite this

Shahnazari, M. ; Lang, D. H. ; Fosmire, G. J. ; Sharkey, Neil ; Mitchell, A. D. ; Leach, R. M. / Strontium administration in young chickens improves bone volume and architecture but does not enhance bone structural and material strength. In: Calcified Tissue International. 2007 ; Vol. 80, No. 3. pp. 160-166.
@article{5ae796fe847640c8bc120bb68458db82,
title = "Strontium administration in young chickens improves bone volume and architecture but does not enhance bone structural and material strength",
abstract = "Genetic selection for rapid body growth in broiler chickens has resulted in adverse effects on the skeletal system exemplified by a higher rate of cortical fractures in leg bones. Strontium (Sr) has been reported to have beneficial effects on bone formation and strength. We supplemented the diet of 300-day-old chicks with increasing dosages of Sr (0{\%}, 0.12{\%}, or 0.24{\%}) to study the capacity of the element to improve bone quality and mechanical integrity. Treatment with Sr increased cortical bone volume and reduced bone porosity as measured by micro-computed tomography. The higher level of Sr significantly reduced bone Ca content (34.7{\%}) relative to controls (37.2{\%}), suggesting that Sr replaced some of the Ca in bone. Material properties determined by the three-point bending test showed that bone in the Sr-treated groups withstood greater deformation prior to fracture. Load to failure and ultimate stress were similar across groups. Our results indicate that Sr treatment in rapidly growing chickens induced positive effects on bone volume but did not improve the breaking strength of long bones.",
author = "M. Shahnazari and Lang, {D. H.} and Fosmire, {G. J.} and Neil Sharkey and Mitchell, {A. D.} and Leach, {R. M.}",
year = "2007",
month = "3",
day = "1",
doi = "10.1007/s00223-006-0176-2",
language = "English (US)",
volume = "80",
pages = "160--166",
journal = "Calcified Tissue International",
issn = "0171-967X",
publisher = "Springer New York",
number = "3",

}

Strontium administration in young chickens improves bone volume and architecture but does not enhance bone structural and material strength. / Shahnazari, M.; Lang, D. H.; Fosmire, G. J.; Sharkey, Neil; Mitchell, A. D.; Leach, R. M.

In: Calcified Tissue International, Vol. 80, No. 3, 01.03.2007, p. 160-166.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Strontium administration in young chickens improves bone volume and architecture but does not enhance bone structural and material strength

AU - Shahnazari, M.

AU - Lang, D. H.

AU - Fosmire, G. J.

AU - Sharkey, Neil

AU - Mitchell, A. D.

AU - Leach, R. M.

PY - 2007/3/1

Y1 - 2007/3/1

N2 - Genetic selection for rapid body growth in broiler chickens has resulted in adverse effects on the skeletal system exemplified by a higher rate of cortical fractures in leg bones. Strontium (Sr) has been reported to have beneficial effects on bone formation and strength. We supplemented the diet of 300-day-old chicks with increasing dosages of Sr (0%, 0.12%, or 0.24%) to study the capacity of the element to improve bone quality and mechanical integrity. Treatment with Sr increased cortical bone volume and reduced bone porosity as measured by micro-computed tomography. The higher level of Sr significantly reduced bone Ca content (34.7%) relative to controls (37.2%), suggesting that Sr replaced some of the Ca in bone. Material properties determined by the three-point bending test showed that bone in the Sr-treated groups withstood greater deformation prior to fracture. Load to failure and ultimate stress were similar across groups. Our results indicate that Sr treatment in rapidly growing chickens induced positive effects on bone volume but did not improve the breaking strength of long bones.

AB - Genetic selection for rapid body growth in broiler chickens has resulted in adverse effects on the skeletal system exemplified by a higher rate of cortical fractures in leg bones. Strontium (Sr) has been reported to have beneficial effects on bone formation and strength. We supplemented the diet of 300-day-old chicks with increasing dosages of Sr (0%, 0.12%, or 0.24%) to study the capacity of the element to improve bone quality and mechanical integrity. Treatment with Sr increased cortical bone volume and reduced bone porosity as measured by micro-computed tomography. The higher level of Sr significantly reduced bone Ca content (34.7%) relative to controls (37.2%), suggesting that Sr replaced some of the Ca in bone. Material properties determined by the three-point bending test showed that bone in the Sr-treated groups withstood greater deformation prior to fracture. Load to failure and ultimate stress were similar across groups. Our results indicate that Sr treatment in rapidly growing chickens induced positive effects on bone volume but did not improve the breaking strength of long bones.

UR - http://www.scopus.com/inward/record.url?scp=33947183493&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33947183493&partnerID=8YFLogxK

U2 - 10.1007/s00223-006-0176-2

DO - 10.1007/s00223-006-0176-2

M3 - Article

C2 - 17340224

AN - SCOPUS:33947183493

VL - 80

SP - 160

EP - 166

JO - Calcified Tissue International

JF - Calcified Tissue International

SN - 0171-967X

IS - 3

ER -