Structural analogues of schweinfurthin F: Probing the steric, electronic, and hydrophobic properties of the D-ring substructure

Natalie C. Ulrich, John G. Kodet, Nolan R. Mente, Craig H. Kuder, John A. Beutler, Raymond J. Hohl, David F. Wiemer

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Abstract

The natural tetracyclic schweinfurthins are potent and selective inhibitors of cell growth in the National Cancer Institute's 60-cell line screen. An interest in determination of their cellular or molecular target has inspired our efforts to prepare both the natural products and analogues. In this paper, chemical synthesis of analogues modified in different olefinic positions, and preliminary results from studies of their biological activity, are reported.

Original languageEnglish (US)
Pages (from-to)1676-1683
Number of pages8
JournalBioorganic and Medicinal Chemistry
Volume18
Issue number4
DOIs
StatePublished - Feb 15 2010

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All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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