Structural analysis of the Hox-3.1 transcription unit and the Hox-3.2-Hox-3.1 intergenic region

A. Awgulewitsch, C. Bieberich, L. Bogarad, C. Shashikant, F. H. Ruddle

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

The mouse Hox gene family is a set of mammalian homeobox genes that may represent developmental control genes. Complete information about the primary structure of these genes is a prerequisite for a systematic analysis of the mechanisms that determine their complex tempero-spatial expression patterns. In this report we describe the complete sequence of the Hox-3.1 locus and provide evidence for several closely spaced transcriptional start sites. Sequence analysis of the 5' region of the Hox-3.1 gene extending to its nearest upstream neighbor, Hox-3.2, allowed us to identify sequences known to be capable of interactions with transcription factors. Several of these sequence motifs are similar to cis-regulatory elements found in the regulatory regions of other known developmentally regulated genes.

Original languageEnglish (US)
Pages (from-to)6428-6432
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume87
Issue number16
DOIs
StatePublished - Sep 5 1990

All Science Journal Classification (ASJC) codes

  • General

Fingerprint Dive into the research topics of 'Structural analysis of the Hox-3.1 transcription unit and the Hox-3.2-Hox-3.1 intergenic region'. Together they form a unique fingerprint.

  • Cite this