Structural biology of bacterial RNA polymerase

Research output: Contribution to journalReview article

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Abstract

Since its discovery and characterization in the early 1960s (Hurwitz, J. The discovery of RNA polymerase. J. Biol. Chem. 2005, 280, 42477–42485), an enormous amount of biochemical, biophysical and genetic data has been collected on bacterial RNA polymerase (RNAP). In the late 1990s, structural information pertaining to bacterial RNAP has emerged that provided unprecedented insights into the function and mechanism of RNA transcription. In this review, I list all structures related to bacterial RNAP (as determined by X-ray crystallography and NMR methods available from the Protein Data Bank), describe their contributions to bacterial transcription research and discuss the role that small molecules play in inhibiting bacterial RNA transcription.

Original languageEnglish (US)
Pages (from-to)848-864
Number of pages17
JournalBiomolecules
Volume5
Issue number2
DOIs
StatePublished - May 11 2015

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All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology

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