Structure and activity of glycosylphosphatidylinositol anchors of Plasmodium falciparum

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26 Scopus citations

Abstract

The glycosylphosphatidylinositol (GPI) anchors of Plasmodium falciparum are thought to be etiologic agents of malaria based on their ability to induce proinflammatory cytokine production by macrophages and cause symptoms that resemble severe malaria illness in animals. This review summarizes the published information on the structures of P. falciparum GPIs, structure-activity relationship, and anti-GPI antibodies in the host.

Original languageEnglish (US)
Pages (from-to)983-990
Number of pages8
JournalMicrobes and Infection
Volume4
Issue number9
DOIs
StatePublished - 2002

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Infectious Diseases

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