TY - JOUR
T1 - Structure and function of Tec family kinase Itk
AU - Qia, Qian
AU - Kannana, Arun Kumar
AU - August, Avery
N1 - Funding Information:
We thank the members of the August lab for their helpful comments. Supported by National Institute of Health grants AI51626, AI065566 and AI073955 to A.A. We apologize to those workers in the field whom we could not directly reference their work due to space limitations.
Publisher Copyright:
© Walter de Gruyter Berlin Boston 2011.
PY - 2011/6/1
Y1 - 2011/6/1
N2 - Itk is a member of the Tec family of kinases that is expressed predominantly in T cells. Itk regulates the T cell receptor signaling pathway to modulate T cell development and T helper cell differentiation, particularly Th2 differentiation. Itk is also important for the development and function of iNKT cells. In this review we discuss current progress on our understanding of the structure, activation and signaling pathway of Itk, in addition to inhibitors that have been developed, which target this kinase. We also place in context the function of Itk, available inhibitors and potential use in treating disease.
AB - Itk is a member of the Tec family of kinases that is expressed predominantly in T cells. Itk regulates the T cell receptor signaling pathway to modulate T cell development and T helper cell differentiation, particularly Th2 differentiation. Itk is also important for the development and function of iNKT cells. In this review we discuss current progress on our understanding of the structure, activation and signaling pathway of Itk, in addition to inhibitors that have been developed, which target this kinase. We also place in context the function of Itk, available inhibitors and potential use in treating disease.
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U2 - 10.1515/bmc.2011.020
DO - 10.1515/bmc.2011.020
M3 - Review article
AN - SCOPUS:84915784818
SN - 1868-5021
VL - 2
SP - 223
EP - 232
JO - Biomolecular Concepts
JF - Biomolecular Concepts
IS - 3
ER -