Structure and timescale analysis in genetic regulatory networks

Madalena Chaves, Eduardo D. Sontag, Réka Albert

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

Regulation of gene expression is achieved through networks of interactions among genes and gene products. Genetic networks are sometimes described in a qualitative way, for instance by means of discrete or even Boolean models. Even when such models accurately reflect the basic structure of interactions, they are in general not suitable for robustness analysis, as one needs to study the effect of biologically-relevant perturbations on the dynamics of the system. This work is concerned with the study of the robustness and fragility of gene regulation networks to variability in the timescales of the distinct biological processes involved. It explores and compares two methods: introducing asynchronous updates in a Boolean model, or integrating the Boolean rules in a continuous, piecewise linear model. As an example, the segment polarity network of the fruit fly is analyzed. A theoretical characterization is given of the model's ability to predict the correct development of the segmented embryo, in terms of the specific timescales of the various regulation interactions.

Original languageEnglish (US)
Title of host publicationProceedings of the 45th IEEE Conference on Decision and Control 2006, CDC
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages2358-2363
Number of pages6
ISBN (Print)1424401712, 9781424401710
DOIs
StatePublished - 2006
Event45th IEEE Conference on Decision and Control 2006, CDC - San Diego, CA, United States
Duration: Dec 13 2006Dec 15 2006

Publication series

NameProceedings of the IEEE Conference on Decision and Control
ISSN (Print)0191-2216

Other

Other45th IEEE Conference on Decision and Control 2006, CDC
CountryUnited States
CitySan Diego, CA
Period12/13/0612/15/06

All Science Journal Classification (ASJC) codes

  • Control and Systems Engineering
  • Modeling and Simulation
  • Control and Optimization

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    Chaves, M., Sontag, E. D., & Albert, R. (2006). Structure and timescale analysis in genetic regulatory networks. In Proceedings of the 45th IEEE Conference on Decision and Control 2006, CDC (pp. 2358-2363). [4177303] (Proceedings of the IEEE Conference on Decision and Control). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/cdc.2006.376804