Structure-function relationships among RNA-dependent RNA polymerases

Kenneth K.S. Ng, Jamie Jon Arnold, Craig Eugene Cameron

Research output: Chapter in Book/Report/Conference proceedingChapter

128 Citations (Scopus)

Abstract

RNA-dependent RNA polymerases (RdRPs) play key roles in viral transcription and genome replication, as well as epigenetic and post-transcriptional control of cellular gene expression. In this article, we review the crystallographic, biochemical, and molecular genetic data available for viral RdRPs that have led to a detailed description of substrate and cofactor binding, fidelity of nucleotide selection and incorporation, and catalysis. It is likely that the cellular RdRPs will share some of the basic structural and mechanistic principles gleaned from studies of viral RdRPs. Therefore, studies of the viral RdRP establish a framework for the study of cellular RdRPs, an important yet understudied class of nucleic acid polymerases.

Original languageEnglish (US)
Title of host publicationRNA Interference
EditorsPatrick Paddison, Peter Vogt
Pages137-156
Number of pages20
DOIs
StatePublished - Dec 1 2008

Publication series

NameCurrent Topics in Microbiology and Immunology
Volume320
ISSN (Print)0070-217X

Fingerprint

RNA Replicase
Viral RNA
Molecular Biology
Viral Genome
Catalysis
Epigenomics
Nucleic Acids
Nucleotides
Gene Expression

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Microbiology
  • Immunology
  • Microbiology (medical)

Cite this

Ng, K. K. S., Arnold, J. J., & Cameron, C. E. (2008). Structure-function relationships among RNA-dependent RNA polymerases. In P. Paddison, & P. Vogt (Eds.), RNA Interference (pp. 137-156). (Current Topics in Microbiology and Immunology; Vol. 320). https://doi.org/10.1007/978-3-540-75157-1_7
Ng, Kenneth K.S. ; Arnold, Jamie Jon ; Cameron, Craig Eugene. / Structure-function relationships among RNA-dependent RNA polymerases. RNA Interference. editor / Patrick Paddison ; Peter Vogt. 2008. pp. 137-156 (Current Topics in Microbiology and Immunology).
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Ng, KKS, Arnold, JJ & Cameron, CE 2008, Structure-function relationships among RNA-dependent RNA polymerases. in P Paddison & P Vogt (eds), RNA Interference. Current Topics in Microbiology and Immunology, vol. 320, pp. 137-156. https://doi.org/10.1007/978-3-540-75157-1_7

Structure-function relationships among RNA-dependent RNA polymerases. / Ng, Kenneth K.S.; Arnold, Jamie Jon; Cameron, Craig Eugene.

RNA Interference. ed. / Patrick Paddison; Peter Vogt. 2008. p. 137-156 (Current Topics in Microbiology and Immunology; Vol. 320).

Research output: Chapter in Book/Report/Conference proceedingChapter

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Ng KKS, Arnold JJ, Cameron CE. Structure-function relationships among RNA-dependent RNA polymerases. In Paddison P, Vogt P, editors, RNA Interference. 2008. p. 137-156. (Current Topics in Microbiology and Immunology). https://doi.org/10.1007/978-3-540-75157-1_7