Structure of Chicken Annexin V at 2.25-Å Resolution

Maria C. Bewley, Catherine M. Boustead, John H. Walker, David A. Walle, Robert Huber

Research output: Contribution to journalArticlepeer-review

56 Scopus citations

Abstract

The crystal structure of chicken annexin V has been solved by molecular replacement and refined at 2.25 Å. The final R factor is 19.7% with good geometry. The chicken annexin V structure is very similar to the human annexin V structure, with four similar domains each containing five helices. The structure includes three calcium ions in domains I, II, and IV, each bound by the characteristic K-G-X-G-T-(38 residues)-D/E motif. In view of the structural similarity between human and chicken annexin V, we suggest that they have a common vital function which developed early in evolutionary history.

Original languageEnglish (US)
Pages (from-to)3923-3929
Number of pages7
JournalBiochemistry
Volume32
Issue number15
DOIs
StatePublished - Apr 1 1993

All Science Journal Classification (ASJC) codes

  • Biochemistry

Fingerprint Dive into the research topics of 'Structure of Chicken Annexin V at 2.25-Å Resolution'. Together they form a unique fingerprint.

Cite this