Structure of Chicken Annexin V at 2.25-Å Resolution

Maria Bewley, Catherine M. Boustead, John H. Walker, David A. Walle, Robert Huber

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

The crystal structure of chicken annexin V has been solved by molecular replacement and refined at 2.25 Å. The final R factor is 19.7% with good geometry. The chicken annexin V structure is very similar to the human annexin V structure, with four similar domains each containing five helices. The structure includes three calcium ions in domains I, II, and IV, each bound by the characteristic K-G-X-G-T-(38 residues)-D/E motif. In view of the structural similarity between human and chicken annexin V, we suggest that they have a common vital function which developed early in evolutionary history.

Original languageEnglish (US)
Pages (from-to)3923-3929
Number of pages7
JournalBiochemistry
Volume32
Issue number15
DOIs
StatePublished - Apr 1 1993

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Annexin A5
Chickens
R Factors
Crystal structure
History
Ions
Calcium
Geometry

All Science Journal Classification (ASJC) codes

  • Biochemistry

Cite this

Bewley, M., Boustead, C. M., Walker, J. H., Walle, D. A., & Huber, R. (1993). Structure of Chicken Annexin V at 2.25-Å Resolution. Biochemistry, 32(15), 3923-3929. https://doi.org/10.1021/bi00066a011
Bewley, Maria ; Boustead, Catherine M. ; Walker, John H. ; Walle, David A. ; Huber, Robert. / Structure of Chicken Annexin V at 2.25-Å Resolution. In: Biochemistry. 1993 ; Vol. 32, No. 15. pp. 3923-3929.
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Bewley, M, Boustead, CM, Walker, JH, Walle, DA & Huber, R 1993, 'Structure of Chicken Annexin V at 2.25-Å Resolution', Biochemistry, vol. 32, no. 15, pp. 3923-3929. https://doi.org/10.1021/bi00066a011

Structure of Chicken Annexin V at 2.25-Å Resolution. / Bewley, Maria; Boustead, Catherine M.; Walker, John H.; Walle, David A.; Huber, Robert.

In: Biochemistry, Vol. 32, No. 15, 01.04.1993, p. 3923-3929.

Research output: Contribution to journalArticle

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AB - The crystal structure of chicken annexin V has been solved by molecular replacement and refined at 2.25 Å. The final R factor is 19.7% with good geometry. The chicken annexin V structure is very similar to the human annexin V structure, with four similar domains each containing five helices. The structure includes three calcium ions in domains I, II, and IV, each bound by the characteristic K-G-X-G-T-(38 residues)-D/E motif. In view of the structural similarity between human and chicken annexin V, we suggest that they have a common vital function which developed early in evolutionary history.

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Bewley M, Boustead CM, Walker JH, Walle DA, Huber R. Structure of Chicken Annexin V at 2.25-Å Resolution. Biochemistry. 1993 Apr 1;32(15):3923-3929. https://doi.org/10.1021/bi00066a011