Structure of serum response factor core bound to DNA

Luca Pellegrini, Song Tan, Timothy J. Richmond

Research output: Contribution to journalArticle

281 Scopus citations

Abstract

The human serum response factor is a transcription factor belonging to the MADS domain protein family with members characterized from the plant and animal kingdoms. The X-ray crystal structure of the serum response factor core in a specific-recognition DNA complex shows that the functions of DNA binding, dimerization and accessory-factor interaction are compactly integrated into a novel protein unit. The intrinsic and induced conformation of the serum response element DNA is the principal DNA feature recognized in the specific complex.

Original languageEnglish (US)
Pages (from-to)490-498
Number of pages9
JournalNature
Volume376
Issue number6540
DOIs
StatePublished - Aug 10 1995

All Science Journal Classification (ASJC) codes

  • General

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    Pellegrini, L., Tan, S., & Richmond, T. J. (1995). Structure of serum response factor core bound to DNA. Nature, 376(6540), 490-498. https://doi.org/10.1038/376490a0