Structure of the rat α1-acid glycoprotein gene

Y. C.J. Liao, J. M. Taylor, J. L. Vannice, G. A. Clawson, E. A. Smuckler

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

The complete nucleotide sequence of the rat α1-acid glycoprotein gene has been determined from an isolated lambda recombinant bacteriophage. Southern blot analysis and DNA sequencing indicate that there is only one gene per genome; it contains six exons and is located within a 3,200-base-pair fragment starting from a TATA box and extending to the polyadenylation signal AATAAA. Transcription starts 37 base pairs upstream from the beginning of the translation codon ATG. The TATA box (TATAAA) lies 26 base pairs upstream from this site. The gene contains several potential glucocorticoid receptor-binding sites, both inside and outside the structural gene.

Original languageEnglish (US)
Pages (from-to)3634-3639
Number of pages6
JournalMolecular and cellular biology
Volume5
Issue number12
DOIs
StatePublished - 1985

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cell Biology

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