Structured antedependence models for functional mapping of multiple longitudinal traits

Wei Zhao, Wei Hou, Ramon C. Littell, Rongling Wu

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

In this article, we present a statistical model for mapping quantitative trait loci (QTL) that determine growth trajectories of two correlated traits during ontogenetic development. This model is derived within the maximum likelihood context, incorporated by mathematical aspects of growth processes to model the mean vector and by structured antedependence (SAD) models to approximate time-dependent covariance matrices for longitudinal traits. It provides a quantitative framework for testing the relative importance of two mechanisms, pleiotropy and linkage, in contributing to genetic correlations during ontogeny. This model has been employed to map QTL a ecting stem height and diameter growth trajectories in an interspecific hybrid progeny of Populus, leading to the successful discovery of three pleiotropic QTL on different linkage groups. The implications of this model for genetic mapping within a broader context are discussed.

Original languageEnglish (US)
Article number33
Pages (from-to)i-26
JournalStatistical Applications in Genetics and Molecular Biology
Volume4
Issue number1
DOIs
StatePublished - Nov 16 2005

All Science Journal Classification (ASJC) codes

  • Statistics and Probability
  • Molecular Biology
  • Genetics
  • Computational Mathematics

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