Studies of folding and misfolding using simplified models

Research output: Contribution to journalReview article

61 Citations (Scopus)

Abstract

Computer simulations are as vital to our studies of biological systems as experiments. They bridge and rationalize experimental observations, extend the experimental 'field of view', which is often limited to a specific time or length scale, and, most importantly, provide novel insights into biological systems, offering hypotheses about yet-to-be uncovered phenomena. These hypotheses spur further experimental discoveries. Simplified molecular models have a special place in the field of computational biology. Branded as less accurate than all-atom protein models, they have offered what all-atom molecular dynamics simulations could not - the resolution of the length and time scales of biological phenomena. Not only have simplified models proven to be accurate in explaining or reproducing several biological phenomena, they have also offered a novel multiscale computational strategy for accessing a broad range of time and length scales upon integration with traditional all-atom simulations. Recent computer simulations of simplified models have shaken or advanced the established understanding of biological phenomena. It was demonstrated that simplified models can be as accurate as traditional molecular dynamics approaches in identifying native conformations of proteins. Their application to protein structure prediction yielded phenomenal accuracy in recapitulating native protein conformations. New studies that utilize the synergy of simplified protein models with all-atom models and experiments yielded novel insights into complex biological processes, such as protein folding, aggregation and the formation of large protein complexes.

Original languageEnglish (US)
Pages (from-to)79-85
Number of pages7
JournalCurrent Opinion in Structural Biology
Volume16
Issue number1
DOIs
StatePublished - Feb 1 2006

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Biological Phenomena
Protein Conformation
Molecular Dynamics Simulation
Computer Simulation
Proteins
Molecular Models
Protein Folding
Computational Biology

All Science Journal Classification (ASJC) codes

  • Structural Biology
  • Molecular Biology

Cite this

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Studies of folding and misfolding using simplified models. / Dokholyan, Nikolay.

In: Current Opinion in Structural Biology, Vol. 16, No. 1, 01.02.2006, p. 79-85.

Research output: Contribution to journalReview article

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