Studies of the 6.7 family of dispersed genomic fragments within the MHC class I region

Laurent Pichon, Charles Venditti, James Harris, Amy Ten Elshof, Mario Pinelli, Michael Chorney

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Searches for MHC-encoded disease susceptibility genes have led to considerable knowledge of the content of the class I region. In an effort to further understand the nature of the five 6.7 family members previously mapped to this region of the genome, we have further analyzed the cross-reactive members of the family and have observed additional genomic instability within the HLA-A subregion. Such genomic variation may underscore the slower evolutionary rates of the HLA-A allelic family and the extended linkage disequilibrium of markers distal to this locus. Moreover, one of the largest genes associated with a member of the 6.7 family, the 3.8-1 gene found proximal to HLA-B, was found to demonstrate limited, composite similarity to RAG2 and complement C4a gene sequences. A pancreas-specific transcript embedded in a 6.7 cross-reactive fragment was found distal to HLA-H and suggests that the fragments have remained linked to transcriptionally active chromatin comprised of both a major class I gene and a second novel coding sequence since the time of their dispersal. The absence of a 6.7 fragment in the HLA-B subregions of higher nonhuman primates lends credence to the possibility that the great apes have suffered a recent deletion event within this region following the emergence of Homo sapiens.

Original languageEnglish (US)
Pages (from-to)131-140
Number of pages10
JournalExperimental and Clinical Immunogenetics
Volume14
Issue number2
StatePublished - Oct 1 1997

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HLA-A Antigens
HLA-B Antigens
Complement C4a
Genes
MHC Class I Genes
Genomic Instability
Disease Susceptibility
Linkage Disequilibrium
Hominidae
Primates
Chromatin
Pancreas
Genome

All Science Journal Classification (ASJC) codes

  • Immunology
  • Genetics
  • Genetics(clinical)

Cite this

Pichon, L., Venditti, C., Harris, J., Elshof, A. T., Pinelli, M., & Chorney, M. (1997). Studies of the 6.7 family of dispersed genomic fragments within the MHC class I region. Experimental and Clinical Immunogenetics, 14(2), 131-140.
Pichon, Laurent ; Venditti, Charles ; Harris, James ; Elshof, Amy Ten ; Pinelli, Mario ; Chorney, Michael. / Studies of the 6.7 family of dispersed genomic fragments within the MHC class I region. In: Experimental and Clinical Immunogenetics. 1997 ; Vol. 14, No. 2. pp. 131-140.
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Pichon, L, Venditti, C, Harris, J, Elshof, AT, Pinelli, M & Chorney, M 1997, 'Studies of the 6.7 family of dispersed genomic fragments within the MHC class I region', Experimental and Clinical Immunogenetics, vol. 14, no. 2, pp. 131-140.

Studies of the 6.7 family of dispersed genomic fragments within the MHC class I region. / Pichon, Laurent; Venditti, Charles; Harris, James; Elshof, Amy Ten; Pinelli, Mario; Chorney, Michael.

In: Experimental and Clinical Immunogenetics, Vol. 14, No. 2, 01.10.1997, p. 131-140.

Research output: Contribution to journalArticle

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Pichon L, Venditti C, Harris J, Elshof AT, Pinelli M, Chorney M. Studies of the 6.7 family of dispersed genomic fragments within the MHC class I region. Experimental and Clinical Immunogenetics. 1997 Oct 1;14(2):131-140.