Studies on lactams. Part 45. Some carbocyclic analogues of cephalosporin

Ajay K. Bose, Shantilal G. Amin, Jagdish C. Kapur, Maghar S. Manhas

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Abstract

Several polycyclic β-lactams have been synthesized by the reactions of cyclic imines with acid chlorides in the presence of triethylamine. The azido-functions in these β-lactams were reduced to amino-groups, which were then acylated with phenylacetyl chloride to introduce the penicillin G side chain. Some carbocyclic analogues of cephalosporin were found to possess antibacterial activity.

Original languageEnglish (US)
Pages (from-to)2193-2197
Number of pages5
JournalJournal of the Chemical Society, Perkin Transactions 1
Issue number20
Publication statusPublished - Dec 1 1976

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All Science Journal Classification (ASJC) codes

  • Chemistry(all)

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