Studies on lactams. Part 45. Some carbocyclic analogues of cephalosporin

Ajay K. Bose, Shantilal G. Amin, Jagdish C. Kapur, Maghar S. Manhas

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Several polycyclic β-lactams have been synthesized by the reactions of cyclic imines with acid chlorides in the presence of triethylamine. The azido-functions in these β-lactams were reduced to amino-groups, which were then acylated with phenylacetyl chloride to introduce the penicillin G side chain. Some carbocyclic analogues of cephalosporin were found to possess antibacterial activity.

Original languageEnglish (US)
Pages (from-to)2193-2197
Number of pages5
JournalJournal of the Chemical Society, Perkin Transactions 1
Issue number20
StatePublished - Dec 1 1976

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Lactams
Cephalosporins
Chlorides
Imines
Penicillin G
Acids
triethylamine

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

Cite this

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Studies on lactams. Part 45. Some carbocyclic analogues of cephalosporin. / Bose, Ajay K.; Amin, Shantilal G.; Kapur, Jagdish C.; Manhas, Maghar S.

In: Journal of the Chemical Society, Perkin Transactions 1, No. 20, 01.12.1976, p. 2193-2197.

Research output: Contribution to journalArticle

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