Studies on serum stimulation of mouse fibroblast migration

L. Wolf, A. Lipton

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Abstract

Evidence is presented that the factor present in rat serum that promotes the migration of mouse fibroblasts (3T3) is a high mol. wt molecule. Amino acids, Mg2+ and Ca2+ are essential for full expression of activity. Once exposed to serum there is an 8-10 h lag period before cell migration can be detected. Cycloheximide, velban, colchicine, actinomycin D, and cytochalasin B, all inhibit cellular migration from a wound edge.

Original languageEnglish (US)
Pages (from-to)499-502
Number of pages4
JournalExperimental Cell Research
Volume80
Issue number2
DOIs
Publication statusPublished - Aug 1973

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All Science Journal Classification (ASJC) codes

  • Cell Biology

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