Studies on the synthesis and degradation of light and heavy chains of cardiac myosin

J. Wikman Coffelt, R. Zelis, C. Fenner, D. T. Mason

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

The relative rate of degradation of the light and heavy chains of cardiac myosin was studied by the double isotope technique in which a single injection of [3H]leucine was administered 12 days prior to [14C]leucine in rats. As indicated by 14C:3H ratios of the purified myosin fractions, the light and heavy chains were degraded at heterogeneous rates, the heavy chains having a turnover rate twice that of the light chains.

Original languageEnglish (US)
Pages (from-to)5206-5207
Number of pages2
JournalJournal of Biological Chemistry
Volume248
Issue number14
StatePublished - 1973

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'Studies on the synthesis and degradation of light and heavy chains of cardiac myosin'. Together they form a unique fingerprint.

Cite this