The relative rate of degradation of the light and heavy chains of cardiac myosin was studied by the double isotope technique in which a single injection of [3H]leucine was administered 12 days prior to [14C]leucine in rats. As indicated by 14C:3H ratios of the purified myosin fractions, the light and heavy chains were degraded at heterogeneous rates, the heavy chains having a turnover rate twice that of the light chains.
|Original language||English (US)|
|Number of pages||2|
|Journal||Journal of Biological Chemistry|
|State||Published - 1973|
All Science Journal Classification (ASJC) codes
- Molecular Biology
- Cell Biology