Studies on the synthesis and degradation of light and heavy chains of cardiac myosin

J. Wikman Coffelt, Robert Zelis, C. Fenner, D. T. Mason

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The relative rate of degradation of the light and heavy chains of cardiac myosin was studied by the double isotope technique in which a single injection of [3H]leucine was administered 12 days prior to [14C]leucine in rats. As indicated by 14C:3H ratios of the purified myosin fractions, the light and heavy chains were degraded at heterogeneous rates, the heavy chains having a turnover rate twice that of the light chains.

Original languageEnglish (US)
Pages (from-to)5206-5207
Number of pages2
JournalJournal of Biological Chemistry
Issue number14
Publication statusPublished - Dec 1 1973


All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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