Study on the antimicrobial properties of citrate-based biodegradable polymers

Lee Chun Su, Zhiwei Xie, Yi Zhang, Kytai Truong Nguyen, Jian Yang

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Citrate-based polymers possess unique advantages for various biomedical applications since citric acid is a natural metabolism product, which is biocompatible and antimicrobial. In polymer synthesis, citric acid also provides multiple functional groups to control the crosslinking of polymers and active binding sites for further conjugation of biomolecules. Our group recently developed a number of citrate-based polymers for various biomedical applications by taking advantage of their controllable chemical, mechanical, and biological characteristics. In this study, various citric acid derived biodegradable polymers were synthesized and investigated for their physicochemical and antimicrobial properties. Results indicate that citric acid derived polymers reduced bacterial proliferation to different degrees based on their chemical composition. Among the studied polymers, poly(octamethylene citrate) showed ~70-80% suppression to microbe proliferation, owing to its relatively higher ratio of citric acid contents. Crosslinked urethane-doped polyester elastomers and biodegradable photoluminescent polymers also exhibited significant bacteria reduction of ~20 and ~50% for Staphylococcus aureus and Escherichia coli, respectively. Thus, the intrinsic antibacterial properties in citrate-based polymers enable them to inhibit bacteria growth without incorporation of antibiotics, silver nanoparticles, and other traditional bacteria-killing agents suggesting that the citrate-based polymers are unique beneficial materials for wound dressing, tissue engineering, and other potential medical applications where antimicrobial property is desired.

Original languageEnglish (US)
Article number23
JournalFrontiers in Bioengineering and Biotechnology
Volume2
Issue numberJUL
DOIs
StatePublished - Jan 1 2014

Fingerprint

Biodegradable polymers
Citric Acid
Polymers
Citric acid
Bacteria
Elastomers
Bioelectric potentials
Biomolecules
Medical applications
Antibiotics
Binding sites
Tissue engineering
Metabolism
Polyesters
Crosslinking
Escherichia coli
Functional groups
Urethane
Tissue Engineering
Bandages

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Bioengineering
  • Histology
  • Biomedical Engineering

Cite this

Su, Lee Chun ; Xie, Zhiwei ; Zhang, Yi ; Nguyen, Kytai Truong ; Yang, Jian. / Study on the antimicrobial properties of citrate-based biodegradable polymers. In: Frontiers in Bioengineering and Biotechnology. 2014 ; Vol. 2, No. JUL.
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abstract = "Citrate-based polymers possess unique advantages for various biomedical applications since citric acid is a natural metabolism product, which is biocompatible and antimicrobial. In polymer synthesis, citric acid also provides multiple functional groups to control the crosslinking of polymers and active binding sites for further conjugation of biomolecules. Our group recently developed a number of citrate-based polymers for various biomedical applications by taking advantage of their controllable chemical, mechanical, and biological characteristics. In this study, various citric acid derived biodegradable polymers were synthesized and investigated for their physicochemical and antimicrobial properties. Results indicate that citric acid derived polymers reduced bacterial proliferation to different degrees based on their chemical composition. Among the studied polymers, poly(octamethylene citrate) showed ~70-80{\%} suppression to microbe proliferation, owing to its relatively higher ratio of citric acid contents. Crosslinked urethane-doped polyester elastomers and biodegradable photoluminescent polymers also exhibited significant bacteria reduction of ~20 and ~50{\%} for Staphylococcus aureus and Escherichia coli, respectively. Thus, the intrinsic antibacterial properties in citrate-based polymers enable them to inhibit bacteria growth without incorporation of antibiotics, silver nanoparticles, and other traditional bacteria-killing agents suggesting that the citrate-based polymers are unique beneficial materials for wound dressing, tissue engineering, and other potential medical applications where antimicrobial property is desired.",
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Study on the antimicrobial properties of citrate-based biodegradable polymers. / Su, Lee Chun; Xie, Zhiwei; Zhang, Yi; Nguyen, Kytai Truong; Yang, Jian.

In: Frontiers in Bioengineering and Biotechnology, Vol. 2, No. JUL, 23, 01.01.2014.

Research output: Contribution to journalArticle

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