Sub-milliMorgan map of the proximal part of mouse Chromosome 17 including the hybrid sterility 1 gene

S. Gregorová; M. Mňuková-Fajdelová; Z. Trachtulec; J. Čapková; M. Loudová; M. Hoglund; R. Hamvas; H. Lehrach; V. Vincek; J. Klein; J. Forejt

doi:10.1007/s003359900029

Sub-milliMorgan map of the proximal part of mouse Chromosome 17 including the hybrid sterility 1 gene

S. Gregorová, M. Mňuková-Fajdelová, Z. Trachtulec, J. Čapková, M. Loudová, M. Hoglund, R. Hamvas, H. Lehrach, V. Vincek, J. Klein, J. Forejt

Biology

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

We have generated a high-resolution genetic map, 0.071 cM per backcross animal, of the 13 cM T-H2 region of the mouse Chromosome (Chr) 17. The map contains two phenotypic loci, T and Hst1, 12 RFLP markers, and 24 microsatellite loci. The Hst1 gene was mapped to a chromosomal interval contained within a single 580-kb YAC clone. The FFEH11 YAC is 0.44 cM long and carries, besides the Hst1 gene, five polymorphic DNA markers and recombination breakpoints of six backcross animals. Two candidate genes for Hst1 were identified based on their location and testicular expression. These are Tbp and D17Ph4e. The submilliMorgan map of the T-H2 region revealed significant clustering of (CA)_n loci. The clustering, if shown to be a common feature in the mouse genome, may cause gaps in the physical map of the mouse genome.

Original language	English (US)
Pages (from-to)	107-113
Number of pages	7
Journal	Mammalian Genome
Volume	7
Issue number	2
DOIs	https://doi.org/10.1007/s003359900029
State	Published - 1996

All Science Journal Classification (ASJC) codes

Genetics

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title = "Sub-milliMorgan map of the proximal part of mouse Chromosome 17 including the hybrid sterility 1 gene",

abstract = "We have generated a high-resolution genetic map, 0.071 cM per backcross animal, of the 13 cM T-H2 region of the mouse Chromosome (Chr) 17. The map contains two phenotypic loci, T and Hst1, 12 RFLP markers, and 24 microsatellite loci. The Hst1 gene was mapped to a chromosomal interval contained within a single 580-kb YAC clone. The FFEH11 YAC is 0.44 cM long and carries, besides the Hst1 gene, five polymorphic DNA markers and recombination breakpoints of six backcross animals. Two candidate genes for Hst1 were identified based on their location and testicular expression. These are Tbp and D17Ph4e. The submilliMorgan map of the T-H2 region revealed significant clustering of (CA)n loci. The clustering, if shown to be a common feature in the mouse genome, may cause gaps in the physical map of the mouse genome.",

author = "S. Gregorov{\'a} and M. M{\v n}ukov{\'a}-Fajdelov{\'a} and Z. Trachtulec and J. {\v C}apkov{\'a} and M. Loudov{\'a} and M. Hoglund and R. Hamvas and H. Lehrach and V. Vincek and J. Klein and J. Forejt",

year = "1996",

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pages = "107--113",

journal = "Mammalian Genome",

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Sub-milliMorgan map of the proximal part of mouse Chromosome 17 including the hybrid sterility 1 gene. / Gregorová, S.; Mňuková-Fajdelová, M.; Trachtulec, Z.; Čapková, J.; Loudová, M.; Hoglund, M.; Hamvas, R.; Lehrach, H.; Vincek, V.; Klein, J.; Forejt, J.

In: Mammalian Genome, Vol. 7, No. 2, 1996, p. 107-113.

Research output: Contribution to journal › Article › peer-review

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AU - Gregorová, S.

AU - Mňuková-Fajdelová, M.

AU - Trachtulec, Z.

AU - Čapková, J.

AU - Loudová, M.

AU - Hoglund, M.

AU - Hamvas, R.

AU - Lehrach, H.

AU - Vincek, V.

AU - Klein, J.

AU - Forejt, J.

PY - 1996

Y1 - 1996

N2 - We have generated a high-resolution genetic map, 0.071 cM per backcross animal, of the 13 cM T-H2 region of the mouse Chromosome (Chr) 17. The map contains two phenotypic loci, T and Hst1, 12 RFLP markers, and 24 microsatellite loci. The Hst1 gene was mapped to a chromosomal interval contained within a single 580-kb YAC clone. The FFEH11 YAC is 0.44 cM long and carries, besides the Hst1 gene, five polymorphic DNA markers and recombination breakpoints of six backcross animals. Two candidate genes for Hst1 were identified based on their location and testicular expression. These are Tbp and D17Ph4e. The submilliMorgan map of the T-H2 region revealed significant clustering of (CA)n loci. The clustering, if shown to be a common feature in the mouse genome, may cause gaps in the physical map of the mouse genome.

AB - We have generated a high-resolution genetic map, 0.071 cM per backcross animal, of the 13 cM T-H2 region of the mouse Chromosome (Chr) 17. The map contains two phenotypic loci, T and Hst1, 12 RFLP markers, and 24 microsatellite loci. The Hst1 gene was mapped to a chromosomal interval contained within a single 580-kb YAC clone. The FFEH11 YAC is 0.44 cM long and carries, besides the Hst1 gene, five polymorphic DNA markers and recombination breakpoints of six backcross animals. Two candidate genes for Hst1 were identified based on their location and testicular expression. These are Tbp and D17Ph4e. The submilliMorgan map of the T-H2 region revealed significant clustering of (CA)n loci. The clustering, if shown to be a common feature in the mouse genome, may cause gaps in the physical map of the mouse genome.

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