TY - JOUR
T1 - Sub-milliMorgan map of the proximal part of mouse Chromosome 17 including the hybrid sterility 1 gene
AU - Gregorová, S.
AU - Mňuková-Fajdelová, M.
AU - Trachtulec, Z.
AU - Čapková, J.
AU - Loudová, M.
AU - Hoglund, M.
AU - Hamvas, R.
AU - Lehrach, H.
AU - Vincek, V.
AU - Klein, J.
AU - Forejt, J.
PY - 1996
Y1 - 1996
N2 - We have generated a high-resolution genetic map, 0.071 cM per backcross animal, of the 13 cM T-H2 region of the mouse Chromosome (Chr) 17. The map contains two phenotypic loci, T and Hst1, 12 RFLP markers, and 24 microsatellite loci. The Hst1 gene was mapped to a chromosomal interval contained within a single 580-kb YAC clone. The FFEH11 YAC is 0.44 cM long and carries, besides the Hst1 gene, five polymorphic DNA markers and recombination breakpoints of six backcross animals. Two candidate genes for Hst1 were identified based on their location and testicular expression. These are Tbp and D17Ph4e. The submilliMorgan map of the T-H2 region revealed significant clustering of (CA)n loci. The clustering, if shown to be a common feature in the mouse genome, may cause gaps in the physical map of the mouse genome.
AB - We have generated a high-resolution genetic map, 0.071 cM per backcross animal, of the 13 cM T-H2 region of the mouse Chromosome (Chr) 17. The map contains two phenotypic loci, T and Hst1, 12 RFLP markers, and 24 microsatellite loci. The Hst1 gene was mapped to a chromosomal interval contained within a single 580-kb YAC clone. The FFEH11 YAC is 0.44 cM long and carries, besides the Hst1 gene, five polymorphic DNA markers and recombination breakpoints of six backcross animals. Two candidate genes for Hst1 were identified based on their location and testicular expression. These are Tbp and D17Ph4e. The submilliMorgan map of the T-H2 region revealed significant clustering of (CA)n loci. The clustering, if shown to be a common feature in the mouse genome, may cause gaps in the physical map of the mouse genome.
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U2 - 10.1007/s003359900029
DO - 10.1007/s003359900029
M3 - Article
C2 - 8835526
AN - SCOPUS:1542505494
VL - 7
SP - 107
EP - 113
JO - Mammalian Genome
JF - Mammalian Genome
SN - 0938-8990
IS - 2
ER -