Subcortical evidence for a contribution of arousal to fMRI studies of brain activity

Xiao Liu, Jacco A. De Zwart, Marieke L. Schölvinck, Catie Chang, Frank Q. Ye, David A. Leopold, Jeff H. Duyn

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Cortical activity during periods of rest is punctuated by widespread, synchronous events in both electrophysiological and hemodynamic signals, but their behavioral relevance remains unclear. Here we report that these events correspond to momentary drops in cortical arousal and are associated with activity changes in the basal forebrain and thalamus. Combining fMRI and electrophysiology in macaques, we first establish that fMRI transients co-occur with spectral shifts in local field potentials (LFPs) toward low frequencies. Applying this knowledge to fMRI data from the human connectome project, we find that the fMRI transients are strongest in sensory cortices. Surprisingly, the positive cortical transients occur together with negative transients in focal subcortical areas known to be involved with arousal regulation, most notably the basal forebrain. This subcortical involvement, combined with the prototypical pattern of LFP spectral shifts, suggests that commonly observed widespread variations in fMRI cortical activity are associated with momentary drops in arousal.

Original languageEnglish (US)
Article number395
JournalNature communications
Volume9
Issue number1
DOIs
StatePublished - Dec 1 2018

Fingerprint

arousal
Arousal
brain
Brain
Magnetic Resonance Imaging
potential fields
thalamus
electrophysiology
hemodynamics
cortexes
shift
Connectome
Electrophysiology
low frequencies
Hemodynamics
Macaca
Thalamus

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

Cite this

Liu, X., De Zwart, J. A., Schölvinck, M. L., Chang, C., Ye, F. Q., Leopold, D. A., & Duyn, J. H. (2018). Subcortical evidence for a contribution of arousal to fMRI studies of brain activity. Nature communications, 9(1), [395]. https://doi.org/10.1038/s41467-017-02815-3
Liu, Xiao ; De Zwart, Jacco A. ; Schölvinck, Marieke L. ; Chang, Catie ; Ye, Frank Q. ; Leopold, David A. ; Duyn, Jeff H. / Subcortical evidence for a contribution of arousal to fMRI studies of brain activity. In: Nature communications. 2018 ; Vol. 9, No. 1.
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Liu, X, De Zwart, JA, Schölvinck, ML, Chang, C, Ye, FQ, Leopold, DA & Duyn, JH 2018, 'Subcortical evidence for a contribution of arousal to fMRI studies of brain activity', Nature communications, vol. 9, no. 1, 395. https://doi.org/10.1038/s41467-017-02815-3

Subcortical evidence for a contribution of arousal to fMRI studies of brain activity. / Liu, Xiao; De Zwart, Jacco A.; Schölvinck, Marieke L.; Chang, Catie; Ye, Frank Q.; Leopold, David A.; Duyn, Jeff H.

In: Nature communications, Vol. 9, No. 1, 395, 01.12.2018.

Research output: Contribution to journalArticle

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