Subnanoradian X-ray phase-contrast imaging using a far-field interferometer of nanometric phase gratings

Han Wen, Andrew A. Gomella, Ajay Patel, Susanna K. Lynch, Nicole Y. Morgan, Stasia A. Anderson, Eric E. Bennett, Xianghui Xiao, Chian Liu, Douglas E. Wolfe

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Hard X-ray phase-contrast imaging characterizes the electron density distribution in an object without the need for radiation absorption. The power of phase contrast to resolve subtle changes, such as those in soft tissue structures, lies in its ability to detect minute refractive bending of X-rays. Here we report a far-field, two-arm interferometer based on the new nanometric phase gratings, which can detect X-ray refraction with subnanoradian sensitivity, and at the same time overcomes the fundamental limitation of ultra-narrow bandwidths (Δλ/λ∼10 -4) of the current, most sensitive methods based on crystal interferometers. On a 1.5% bandwidth synchrotron source, we demonstrate clear visualization of blood vessels in unstained mouse organs in simple projection views, with over an order-of-magnitude higher phase contrast than current near-field grating interferometers.

Original languageEnglish (US)
Article number2659
JournalNature communications
Volume4
DOIs
StatePublished - Nov 5 2013

Fingerprint

phase contrast
Interferometers
far fields
interferometers
X-Rays
gratings
Imaging techniques
X rays
bandwidth
radiation absorption
Bandwidth
Synchrotrons
Electronic density of states
x rays
blood vessels
Blood vessels
Refraction
organs
Blood Vessels
mice

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

Cite this

Wen, Han ; Gomella, Andrew A. ; Patel, Ajay ; Lynch, Susanna K. ; Morgan, Nicole Y. ; Anderson, Stasia A. ; Bennett, Eric E. ; Xiao, Xianghui ; Liu, Chian ; Wolfe, Douglas E. / Subnanoradian X-ray phase-contrast imaging using a far-field interferometer of nanometric phase gratings. In: Nature communications. 2013 ; Vol. 4.
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abstract = "Hard X-ray phase-contrast imaging characterizes the electron density distribution in an object without the need for radiation absorption. The power of phase contrast to resolve subtle changes, such as those in soft tissue structures, lies in its ability to detect minute refractive bending of X-rays. Here we report a far-field, two-arm interferometer based on the new nanometric phase gratings, which can detect X-ray refraction with subnanoradian sensitivity, and at the same time overcomes the fundamental limitation of ultra-narrow bandwidths (Δλ/λ∼10 -4) of the current, most sensitive methods based on crystal interferometers. On a 1.5{\%} bandwidth synchrotron source, we demonstrate clear visualization of blood vessels in unstained mouse organs in simple projection views, with over an order-of-magnitude higher phase contrast than current near-field grating interferometers.",
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Wen, H, Gomella, AA, Patel, A, Lynch, SK, Morgan, NY, Anderson, SA, Bennett, EE, Xiao, X, Liu, C & Wolfe, DE 2013, 'Subnanoradian X-ray phase-contrast imaging using a far-field interferometer of nanometric phase gratings', Nature communications, vol. 4, 2659. https://doi.org/10.1038/ncomms3659

Subnanoradian X-ray phase-contrast imaging using a far-field interferometer of nanometric phase gratings. / Wen, Han; Gomella, Andrew A.; Patel, Ajay; Lynch, Susanna K.; Morgan, Nicole Y.; Anderson, Stasia A.; Bennett, Eric E.; Xiao, Xianghui; Liu, Chian; Wolfe, Douglas E.

In: Nature communications, Vol. 4, 2659, 05.11.2013.

Research output: Contribution to journalArticle

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AU - Gomella, Andrew A.

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AU - Liu, Chian

AU - Wolfe, Douglas E.

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