Substance P analogues potentiate the pressor response to microinjection of L-glutamate into laminas I and II of the cat dorsal horn

Christian A. Beyaert, Janeen M. Hill, Marc P. Kaufman

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Microinjection of a substance P analogue (1 mM; 7 or 10 nl) into laminae I and II of the L7 dorsal horn of decerebrate cats significantly potentiated (P < 0.05) the increase in arterial pressure evoked by microinjection of L- glutamate (109 mM; 7 or 10 nl) into these spinal sites. Microinjection of the substance P analogues (i.e., GR73638 and [Sar9, Met(O2)11] -substance P) which were selective NK-1 receptor agonists, had no impact on the cardioacceleration evoked by microinjection of L-glutamate (P > 0.05). In addition, microinjection of these analogues had no effect on the modest and non-significant increase in phrenic nerve discharge evoked by L-glutamate. We conclude that stimulation of NK-I receptors in the superficial laminae of the dorsal horn potentiates the pressor responses to microinjection of L- glutamate.

Original languageEnglish (US)
Pages (from-to)175-179
Number of pages5
JournalBrain research
Volume759
Issue number1
DOIs
StatePublished - Jun 6 1997

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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