Substance P increases rat aortic albumin permeability

Ronald Albert Markle, Michal L. Boyd, Virginia H. Coryell

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

We tested the hypothesis that exogenous substance P (SP) could enhance rat aortic permeability to plasma albumin. Fluorescein-labeled bovine serum albumin was used as the tracer. In vivo normalized albumin mass transfer rates (x10-8 cm/sec) were 9.16 ± 1.73, 14.20 ± 2.76 (P < 0.05) and 20.31 ± 3.31 (P < 0.001) for groups infused i.v. with 0.01 N acetic acid vehicle, 7.4 pmol and 0.74 pmol SP/kg/min for 5 min, respectively. No significant differences from the control group were found in rats receiving 150 pmol, 74 pmol nor 74 fmol SP/kg/min for 5 min. The results indicate that aortic permeability dynamics for plasma albumin can be enhanced by pmol levels of the tachykinin SP.

Original languageEnglish (US)
Pages (from-to)965-969
Number of pages5
JournalLife Sciences
Volume46
Issue number13
DOIs
StatePublished - Jan 1 1990

Fingerprint

Substance P
Rats
Albumins
Permeability
Serum Albumin
Tachykinins
Bovine Serum Albumin
Fluorescein
Acetic Acid
Mass transfer
Control Groups

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Markle, Ronald Albert ; Boyd, Michal L. ; Coryell, Virginia H. / Substance P increases rat aortic albumin permeability. In: Life Sciences. 1990 ; Vol. 46, No. 13. pp. 965-969.
@article{fa1db1373ab24ec1806fda5fe163bc02,
title = "Substance P increases rat aortic albumin permeability",
abstract = "We tested the hypothesis that exogenous substance P (SP) could enhance rat aortic permeability to plasma albumin. Fluorescein-labeled bovine serum albumin was used as the tracer. In vivo normalized albumin mass transfer rates (x10-8 cm/sec) were 9.16 ± 1.73, 14.20 ± 2.76 (P < 0.05) and 20.31 ± 3.31 (P < 0.001) for groups infused i.v. with 0.01 N acetic acid vehicle, 7.4 pmol and 0.74 pmol SP/kg/min for 5 min, respectively. No significant differences from the control group were found in rats receiving 150 pmol, 74 pmol nor 74 fmol SP/kg/min for 5 min. The results indicate that aortic permeability dynamics for plasma albumin can be enhanced by pmol levels of the tachykinin SP.",
author = "Markle, {Ronald Albert} and Boyd, {Michal L.} and Coryell, {Virginia H.}",
year = "1990",
month = "1",
day = "1",
doi = "10.1016/0024-3205(90)90098-C",
language = "English (US)",
volume = "46",
pages = "965--969",
journal = "Life Sciences",
issn = "0024-3205",
publisher = "Elsevier Inc.",
number = "13",

}

Substance P increases rat aortic albumin permeability. / Markle, Ronald Albert; Boyd, Michal L.; Coryell, Virginia H.

In: Life Sciences, Vol. 46, No. 13, 01.01.1990, p. 965-969.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Substance P increases rat aortic albumin permeability

AU - Markle, Ronald Albert

AU - Boyd, Michal L.

AU - Coryell, Virginia H.

PY - 1990/1/1

Y1 - 1990/1/1

N2 - We tested the hypothesis that exogenous substance P (SP) could enhance rat aortic permeability to plasma albumin. Fluorescein-labeled bovine serum albumin was used as the tracer. In vivo normalized albumin mass transfer rates (x10-8 cm/sec) were 9.16 ± 1.73, 14.20 ± 2.76 (P < 0.05) and 20.31 ± 3.31 (P < 0.001) for groups infused i.v. with 0.01 N acetic acid vehicle, 7.4 pmol and 0.74 pmol SP/kg/min for 5 min, respectively. No significant differences from the control group were found in rats receiving 150 pmol, 74 pmol nor 74 fmol SP/kg/min for 5 min. The results indicate that aortic permeability dynamics for plasma albumin can be enhanced by pmol levels of the tachykinin SP.

AB - We tested the hypothesis that exogenous substance P (SP) could enhance rat aortic permeability to plasma albumin. Fluorescein-labeled bovine serum albumin was used as the tracer. In vivo normalized albumin mass transfer rates (x10-8 cm/sec) were 9.16 ± 1.73, 14.20 ± 2.76 (P < 0.05) and 20.31 ± 3.31 (P < 0.001) for groups infused i.v. with 0.01 N acetic acid vehicle, 7.4 pmol and 0.74 pmol SP/kg/min for 5 min, respectively. No significant differences from the control group were found in rats receiving 150 pmol, 74 pmol nor 74 fmol SP/kg/min for 5 min. The results indicate that aortic permeability dynamics for plasma albumin can be enhanced by pmol levels of the tachykinin SP.

UR - http://www.scopus.com/inward/record.url?scp=0025274148&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025274148&partnerID=8YFLogxK

U2 - 10.1016/0024-3205(90)90098-C

DO - 10.1016/0024-3205(90)90098-C

M3 - Article

C2 - 1691812

AN - SCOPUS:0025274148

VL - 46

SP - 965

EP - 969

JO - Life Sciences

JF - Life Sciences

SN - 0024-3205

IS - 13

ER -