Substantia nigra lesions in mercaptopropionic acid induced status epilepticus: a light and electron microscopic study

J. Towfighi, W. A. Kofke, B. K. O'Connell, C. Housman, J. M. Graybeal

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Light microscopic and ultrastructural changes of substantia nigra were studied in paralyzed ventilated rats with status epilepticus induced by mercaptopropionic acid. Some rats were killed at the end of seizure activity and others were examined in varying intervals after the arrest of seizure. The earliest changes were reduction in the size of the neuronal nuclei and chromatin clumping followed by simultaneous distention of axons and dendrites. There was also enlargement of the neuronal perikarya associated with microvacuolation. This neuronal microvacuolation corresponded ultrastructurally to swollen mitochondria with disrupted cristae. These changes were followed by progressive neuronal shrinkage and astrocytic swelling. The swollen astrocytic processes together with swollen neurites gave a spongy appearance to the involved area. The lesion thereafter progressively enlarged and evolved into an area of frank necrosis containing abundant macrophages. This lesion is morphologically different from that produced in cortex and hippocampus by seizure activity or due to the direct effect of excitotoxins. The significance of substantia nigra pars reticularis changes and their pathogenesis are discussed.

Original languageEnglish (US)
Pages (from-to)612-620
Number of pages9
JournalActa Neuropathologica
Volume77
Issue number6
DOIs
StatePublished - Nov 1 1989

Fingerprint

Status Epilepticus
Substantia Nigra
Seizures
Electrons
Light
Acids
Neurotoxins
Neurites
Dendrites
Chromatin
Axons
Hippocampus
Mitochondria
Necrosis
Macrophages

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

Cite this

Towfighi, J. ; Kofke, W. A. ; O'Connell, B. K. ; Housman, C. ; Graybeal, J. M. / Substantia nigra lesions in mercaptopropionic acid induced status epilepticus : a light and electron microscopic study. In: Acta Neuropathologica. 1989 ; Vol. 77, No. 6. pp. 612-620.
@article{49f4fa912e6149c98eea420829f6bc7f,
title = "Substantia nigra lesions in mercaptopropionic acid induced status epilepticus: a light and electron microscopic study",
abstract = "Light microscopic and ultrastructural changes of substantia nigra were studied in paralyzed ventilated rats with status epilepticus induced by mercaptopropionic acid. Some rats were killed at the end of seizure activity and others were examined in varying intervals after the arrest of seizure. The earliest changes were reduction in the size of the neuronal nuclei and chromatin clumping followed by simultaneous distention of axons and dendrites. There was also enlargement of the neuronal perikarya associated with microvacuolation. This neuronal microvacuolation corresponded ultrastructurally to swollen mitochondria with disrupted cristae. These changes were followed by progressive neuronal shrinkage and astrocytic swelling. The swollen astrocytic processes together with swollen neurites gave a spongy appearance to the involved area. The lesion thereafter progressively enlarged and evolved into an area of frank necrosis containing abundant macrophages. This lesion is morphologically different from that produced in cortex and hippocampus by seizure activity or due to the direct effect of excitotoxins. The significance of substantia nigra pars reticularis changes and their pathogenesis are discussed.",
author = "J. Towfighi and Kofke, {W. A.} and O'Connell, {B. K.} and C. Housman and Graybeal, {J. M.}",
year = "1989",
month = "11",
day = "1",
doi = "10.1007/BF00687889",
language = "English (US)",
volume = "77",
pages = "612--620",
journal = "Acta Neuropathologica",
issn = "0001-6322",
publisher = "Springer Verlag",
number = "6",

}

Substantia nigra lesions in mercaptopropionic acid induced status epilepticus : a light and electron microscopic study. / Towfighi, J.; Kofke, W. A.; O'Connell, B. K.; Housman, C.; Graybeal, J. M.

In: Acta Neuropathologica, Vol. 77, No. 6, 01.11.1989, p. 612-620.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Substantia nigra lesions in mercaptopropionic acid induced status epilepticus

T2 - a light and electron microscopic study

AU - Towfighi, J.

AU - Kofke, W. A.

AU - O'Connell, B. K.

AU - Housman, C.

AU - Graybeal, J. M.

PY - 1989/11/1

Y1 - 1989/11/1

N2 - Light microscopic and ultrastructural changes of substantia nigra were studied in paralyzed ventilated rats with status epilepticus induced by mercaptopropionic acid. Some rats were killed at the end of seizure activity and others were examined in varying intervals after the arrest of seizure. The earliest changes were reduction in the size of the neuronal nuclei and chromatin clumping followed by simultaneous distention of axons and dendrites. There was also enlargement of the neuronal perikarya associated with microvacuolation. This neuronal microvacuolation corresponded ultrastructurally to swollen mitochondria with disrupted cristae. These changes were followed by progressive neuronal shrinkage and astrocytic swelling. The swollen astrocytic processes together with swollen neurites gave a spongy appearance to the involved area. The lesion thereafter progressively enlarged and evolved into an area of frank necrosis containing abundant macrophages. This lesion is morphologically different from that produced in cortex and hippocampus by seizure activity or due to the direct effect of excitotoxins. The significance of substantia nigra pars reticularis changes and their pathogenesis are discussed.

AB - Light microscopic and ultrastructural changes of substantia nigra were studied in paralyzed ventilated rats with status epilepticus induced by mercaptopropionic acid. Some rats were killed at the end of seizure activity and others were examined in varying intervals after the arrest of seizure. The earliest changes were reduction in the size of the neuronal nuclei and chromatin clumping followed by simultaneous distention of axons and dendrites. There was also enlargement of the neuronal perikarya associated with microvacuolation. This neuronal microvacuolation corresponded ultrastructurally to swollen mitochondria with disrupted cristae. These changes were followed by progressive neuronal shrinkage and astrocytic swelling. The swollen astrocytic processes together with swollen neurites gave a spongy appearance to the involved area. The lesion thereafter progressively enlarged and evolved into an area of frank necrosis containing abundant macrophages. This lesion is morphologically different from that produced in cortex and hippocampus by seizure activity or due to the direct effect of excitotoxins. The significance of substantia nigra pars reticularis changes and their pathogenesis are discussed.

UR - http://www.scopus.com/inward/record.url?scp=0024511279&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024511279&partnerID=8YFLogxK

U2 - 10.1007/BF00687889

DO - 10.1007/BF00687889

M3 - Article

C2 - 2750479

AN - SCOPUS:0024511279

VL - 77

SP - 612

EP - 620

JO - Acta Neuropathologica

JF - Acta Neuropathologica

SN - 0001-6322

IS - 6

ER -