Successful allogeneic blood stem cell transplantation for aplastic anemia in a patient with renal insufficiency requiring dialysis

T. Hamaki, H. Katori, T. Kami, T. Yamato, H. Yamakado, T. Itoh, E. Kusumi, M. Igarshi, J. Ueyama, Y. Kanda, S. Miyakoshi, Shin Mineishi, S. Morinaga, M. Mukai, M. Hayashi, Y. Takaue, S. Hara, Y. Mutou

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

A 27-year-old man with aplastic anemia and renal insufficiency requiring dialysis underwent allogeneic PBSCT. The preparative regimen consisted of melphalan, ATG and TLI. GVHD prophylaxis consisted of cyclosporine and prednisolone. He was dialyzed prior to administration of melphalan and at 24 and 72 h after it. Otherwise, the dialysis schedule was unchanged, at three times a week. Engraftment was rapid. Regimen-related toxicity was minimal. Pharmacokinetic parameters of melphalan were not significantly altered with its plasma half-life 1.5 h. Patients with renal failure can receive, allogeneic HSCT, and a combination of melphalan, ATG and TLI may serve as an alternative to CY and ATG.

Original languageEnglish (US)
Pages (from-to)195-198
Number of pages4
JournalBone Marrow Transplantation
Volume30
Issue number3
DOIs
StatePublished - Jan 1 2002

Fingerprint

Melphalan
Aplastic Anemia
Stem Cell Transplantation
Renal Insufficiency
Dialysis
Blood Cells
Prednisolone
Cyclosporine
Half-Life
Appointments and Schedules
Pharmacokinetics

All Science Journal Classification (ASJC) codes

  • Hematology
  • Transplantation

Cite this

Hamaki, T. ; Katori, H. ; Kami, T. ; Yamato, T. ; Yamakado, H. ; Itoh, T. ; Kusumi, E. ; Igarshi, M. ; Ueyama, J. ; Kanda, Y. ; Miyakoshi, S. ; Mineishi, Shin ; Morinaga, S. ; Mukai, M. ; Hayashi, M. ; Takaue, Y. ; Hara, S. ; Mutou, Y. / Successful allogeneic blood stem cell transplantation for aplastic anemia in a patient with renal insufficiency requiring dialysis. In: Bone Marrow Transplantation. 2002 ; Vol. 30, No. 3. pp. 195-198.
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abstract = "A 27-year-old man with aplastic anemia and renal insufficiency requiring dialysis underwent allogeneic PBSCT. The preparative regimen consisted of melphalan, ATG and TLI. GVHD prophylaxis consisted of cyclosporine and prednisolone. He was dialyzed prior to administration of melphalan and at 24 and 72 h after it. Otherwise, the dialysis schedule was unchanged, at three times a week. Engraftment was rapid. Regimen-related toxicity was minimal. Pharmacokinetic parameters of melphalan were not significantly altered with its plasma half-life 1.5 h. Patients with renal failure can receive, allogeneic HSCT, and a combination of melphalan, ATG and TLI may serve as an alternative to CY and ATG.",
author = "T. Hamaki and H. Katori and T. Kami and T. Yamato and H. Yamakado and T. Itoh and E. Kusumi and M. Igarshi and J. Ueyama and Y. Kanda and S. Miyakoshi and Shin Mineishi and S. Morinaga and M. Mukai and M. Hayashi and Y. Takaue and S. Hara and Y. Mutou",
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Hamaki, T, Katori, H, Kami, T, Yamato, T, Yamakado, H, Itoh, T, Kusumi, E, Igarshi, M, Ueyama, J, Kanda, Y, Miyakoshi, S, Mineishi, S, Morinaga, S, Mukai, M, Hayashi, M, Takaue, Y, Hara, S & Mutou, Y 2002, 'Successful allogeneic blood stem cell transplantation for aplastic anemia in a patient with renal insufficiency requiring dialysis', Bone Marrow Transplantation, vol. 30, no. 3, pp. 195-198. https://doi.org/10.1038/sj.bmt.1703584

Successful allogeneic blood stem cell transplantation for aplastic anemia in a patient with renal insufficiency requiring dialysis. / Hamaki, T.; Katori, H.; Kami, T.; Yamato, T.; Yamakado, H.; Itoh, T.; Kusumi, E.; Igarshi, M.; Ueyama, J.; Kanda, Y.; Miyakoshi, S.; Mineishi, Shin; Morinaga, S.; Mukai, M.; Hayashi, M.; Takaue, Y.; Hara, S.; Mutou, Y.

In: Bone Marrow Transplantation, Vol. 30, No. 3, 01.01.2002, p. 195-198.

Research output: Contribution to journalArticle

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T1 - Successful allogeneic blood stem cell transplantation for aplastic anemia in a patient with renal insufficiency requiring dialysis

AU - Hamaki, T.

AU - Katori, H.

AU - Kami, T.

AU - Yamato, T.

AU - Yamakado, H.

AU - Itoh, T.

AU - Kusumi, E.

AU - Igarshi, M.

AU - Ueyama, J.

AU - Kanda, Y.

AU - Miyakoshi, S.

AU - Mineishi, Shin

AU - Morinaga, S.

AU - Mukai, M.

AU - Hayashi, M.

AU - Takaue, Y.

AU - Hara, S.

AU - Mutou, Y.

PY - 2002/1/1

Y1 - 2002/1/1

N2 - A 27-year-old man with aplastic anemia and renal insufficiency requiring dialysis underwent allogeneic PBSCT. The preparative regimen consisted of melphalan, ATG and TLI. GVHD prophylaxis consisted of cyclosporine and prednisolone. He was dialyzed prior to administration of melphalan and at 24 and 72 h after it. Otherwise, the dialysis schedule was unchanged, at three times a week. Engraftment was rapid. Regimen-related toxicity was minimal. Pharmacokinetic parameters of melphalan were not significantly altered with its plasma half-life 1.5 h. Patients with renal failure can receive, allogeneic HSCT, and a combination of melphalan, ATG and TLI may serve as an alternative to CY and ATG.

AB - A 27-year-old man with aplastic anemia and renal insufficiency requiring dialysis underwent allogeneic PBSCT. The preparative regimen consisted of melphalan, ATG and TLI. GVHD prophylaxis consisted of cyclosporine and prednisolone. He was dialyzed prior to administration of melphalan and at 24 and 72 h after it. Otherwise, the dialysis schedule was unchanged, at three times a week. Engraftment was rapid. Regimen-related toxicity was minimal. Pharmacokinetic parameters of melphalan were not significantly altered with its plasma half-life 1.5 h. Patients with renal failure can receive, allogeneic HSCT, and a combination of melphalan, ATG and TLI may serve as an alternative to CY and ATG.

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