Successful allogeneic blood stem cell transplantation for aplastic anemia in a patient with renal insufficiency requiring dialysis

T. Hamaki, H. Katori, T. Kami, T. Yamato, H. Yamakado, T. Itoh, E. Kusumi, M. Igarshi, J. Ueyama, Y. Kanda, S. Miyakoshi, S. Mineishi, S. Morinaga, M. Mukai, M. Hayashi, Y. Takaue, S. Hara, Y. Mutou

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

A 27-year-old man with aplastic anemia and renal insufficiency requiring dialysis underwent allogeneic PBSCT. The preparative regimen consisted of melphalan, ATG and TLI. GVHD prophylaxis consisted of cyclosporine and prednisolone. He was dialyzed prior to administration of melphalan and at 24 and 72 h after it. Otherwise, the dialysis schedule was unchanged, at three times a week. Engraftment was rapid. Regimen-related toxicity was minimal. Pharmacokinetic parameters of melphalan were not significantly altered with its plasma half-life 1.5 h. Patients with renal failure can receive, allogeneic HSCT, and a combination of melphalan, ATG and TLI may serve as an alternative to CY and ATG.

Original languageEnglish (US)
Pages (from-to)195-198
Number of pages4
JournalBone Marrow Transplantation
Volume30
Issue number3
DOIs
StatePublished - 2002

All Science Journal Classification (ASJC) codes

  • Hematology
  • Transplantation

Fingerprint Dive into the research topics of 'Successful allogeneic blood stem cell transplantation for aplastic anemia in a patient with renal insufficiency requiring dialysis'. Together they form a unique fingerprint.

Cite this