Sucrose sham feeding decreases accumbens norepinephrine in the rat

Andras Hajnal, Ralph Norgren

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Noradrenergic projections from the dorsomedial medulla reach the shell of the nucleus accumbens (NAcc), a structure implicated in both reward and feeding behavior. Despite this relationship, the effect of food reward on accumbens norepinephrine (NE) remains uninvestigated. In the course of assessing dopamine (DA) in the NAcc during sucrose ingestion [0.03, 0.1, and 0.3 M; Am. J. Physiol., Regul. Integr. Comp. Physiol., 286 (2004) R31], we also analyzed NE in the microdialysis samples from 14 ad-libitum-fed male rats. In contrast to DA, which increased with sucrose concentration (+20-47%) during sham feeding, in the same animals, NE levels were reduced (approximately -20%), regardless of sucrose concentration. These results demonstrate a novel relationship between accumbens DA and NE during orosensory stimulation with a preferred nutrient.

Original languageEnglish (US)
Pages (from-to)43-47
Number of pages5
JournalPhysiology and Behavior
Volume82
Issue number1
DOIs
StatePublished - Jan 1 2004

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Sucrose
Norepinephrine
Dopamine
Nucleus Accumbens
Reward
Food
Microdialysis
Feeding Behavior
Eating

All Science Journal Classification (ASJC) codes

  • Experimental and Cognitive Psychology
  • Behavioral Neuroscience

Cite this

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abstract = "Noradrenergic projections from the dorsomedial medulla reach the shell of the nucleus accumbens (NAcc), a structure implicated in both reward and feeding behavior. Despite this relationship, the effect of food reward on accumbens norepinephrine (NE) remains uninvestigated. In the course of assessing dopamine (DA) in the NAcc during sucrose ingestion [0.03, 0.1, and 0.3 M; Am. J. Physiol., Regul. Integr. Comp. Physiol., 286 (2004) R31], we also analyzed NE in the microdialysis samples from 14 ad-libitum-fed male rats. In contrast to DA, which increased with sucrose concentration (+20-47{\%}) during sham feeding, in the same animals, NE levels were reduced (approximately -20{\%}), regardless of sucrose concentration. These results demonstrate a novel relationship between accumbens DA and NE during orosensory stimulation with a preferred nutrient.",
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Sucrose sham feeding decreases accumbens norepinephrine in the rat. / Hajnal, Andras; Norgren, Ralph.

In: Physiology and Behavior, Vol. 82, No. 1, 01.01.2004, p. 43-47.

Research output: Contribution to journalArticle

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