A novel proton-detected 13C homonuclear correlation experiment is reported at natural abundance, viz., 1H Indirect detected 13C Low-Abundance Single-transition correlation Spectroscopy (HICLASS). HICLASS is based on the evolution of 13C single-quantum single transitions, followed by their mixing, and 1H detection subsequent to heteronuclear transfer. Reduced relaxation losses during the evolution time and partial selectivity in the 1H multiplet structure result in enhanced sensitivity of HICLASS. The superior performance of HICLASS is demonstrated for 1H-detected 13C correlation work.
All Science Journal Classification (ASJC) codes
- Physical and Theoretical Chemistry
- Organic Chemistry