Suppression of cell‐mediated lymphocytotoxicity against minor histocompatibility antigens mediated by Lyt‐1+Lyt−2+ T cells of stimulator‐strain origin

Hans‐Georg ‐G Rammensee, Zoltan A. Nagy, Jan Klein

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Cultured, unprimed spleen cells suppress the generation of cytolytic T lymphocytes when added to mixed lymphocyte culture of cells disparate at minor histocompatibility (H) loci. Cells cultured for 2 to 3 days inhibit cell‐mediated lympholysis specifically in that they suppress only when they carry the same H antigen by which the stimulators activate the responding cells. However, culturing of cells for more than 3 days results also in the generation of nonspecific suppressor cells which inhibit the cell‐mediated lympholysis regardless whether they carry the stimulating antigens. The specific suppressor cells are T lymphocytes of the Lyt‐l+Lyt−2+ type. Fresh, uncultured spleen cells, although ineffective in vitro, can prevent the in vivo priming of minor H‐specific cytotoxic T lymphocyte precursors when injected i.v. into mice incompatible at minor H loci. This suppressive effect of the immunizing inoculum is abolished by irradiation (3300 rds) or by treatment with a monoclonal Thy‐1‐specific antibody and complement. Thus the suppressor T cell demonstrated here is of the “veto” cell type; that is, it probably suppresses minor H‐specific cells when the latter recognize the stimulating antigen on the surface of the suppressor cell itself.

Original languageEnglish (US)
Pages (from-to)930-934
Number of pages5
JournalEuropean Journal of Immunology
Issue number11
StatePublished - 1982

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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