Suppression of human melanoma metastasis by introduction of chromosome 6 may be partially due to inhibition of motility, but not to inhibition of invasion

Jun You, Mary E. Miele, Cheng Dong, Danny R. Welch

Research output: Contribution to journalArticle

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Abstract

Active cellular motility and invasion play essential roles in metastasis. Introduction of normal, neo-tagged human chromosome 6 (neo6) into highly metastatic human melanoma cell line C8161 results in complete suppression of metastasis in vivo. To understand the mechanism by which metastasis was inhibited in neo6/C8161 hybrids, two in vitro assays, pseudopod protrusion and Membrane Invasion Culture System, were used to measure motility and invasion, respectively. neo6/C8161 hybrids are much less motile although they remained invasive, indicating that a metastasis-suppressor gene(s) on human chromosome 6 may regulate cellular motility, thereby inhibiting metastasis.

Original languageEnglish (US)
Pages (from-to)476-484
Number of pages9
JournalBiochemical and Biophysical Research Communications
Volume208
Issue number2
DOIs
StatePublished - Mar 17 1995

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All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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