Suppression of p16 Induces mTORC1-Mediated Nucleotide Metabolic Reprogramming

Raquel Buj, Chi Wei Chen, Erika S. Dahl, Kelly E. Leon, Rostislav Kuskovsky, Natella Maglakelidze, Maithili Navaratnarajah, Gao Zhang, Mary T. Doan, Helen Jiang, Michael Zaleski, Lydia Kutzler, Holly Lacko, Yiling Lu, Gordon B. Mills, Raghavendra Gowda, Gavin Robertson, Joshua Warrick, Meenhard Herlyn, Yuka Imamura & 4 others Scot Kimball, David Degraff, Nathaniel W. Snyder, Katherine Aird

Research output: Contribution to journalArticle

Abstract

Senescence bypass through p16 loss predisposes to transformation and tumorigenesis. Buj et al. found that the loss of p16 upregulates nucleotide metabolism through increased mTORC1-mediated translation of RPIA to bypass senescence in an RB-independent manner. Thus, the mTORC1-RPIA axis is a metabolic vulnerability for p16-null cancers.

Original languageEnglish (US)
JournalCell Reports
DOIs
StateAccepted/In press - Jan 1 2019

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Nucleotides
Metabolism
Carcinogenesis
Up-Regulation
Neoplasms
mechanistic target of rapamycin complex 1

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Buj, R., Chen, C. W., Dahl, E. S., Leon, K. E., Kuskovsky, R., Maglakelidze, N., ... Aird, K. (Accepted/In press). Suppression of p16 Induces mTORC1-Mediated Nucleotide Metabolic Reprogramming. Cell Reports. https://doi.org/10.1016/j.celrep.2019.07.084
Buj, Raquel ; Chen, Chi Wei ; Dahl, Erika S. ; Leon, Kelly E. ; Kuskovsky, Rostislav ; Maglakelidze, Natella ; Navaratnarajah, Maithili ; Zhang, Gao ; Doan, Mary T. ; Jiang, Helen ; Zaleski, Michael ; Kutzler, Lydia ; Lacko, Holly ; Lu, Yiling ; Mills, Gordon B. ; Gowda, Raghavendra ; Robertson, Gavin ; Warrick, Joshua ; Herlyn, Meenhard ; Imamura, Yuka ; Kimball, Scot ; Degraff, David ; Snyder, Nathaniel W. ; Aird, Katherine. / Suppression of p16 Induces mTORC1-Mediated Nucleotide Metabolic Reprogramming. In: Cell Reports. 2019.
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abstract = "Senescence bypass through p16 loss predisposes to transformation and tumorigenesis. Buj et al. found that the loss of p16 upregulates nucleotide metabolism through increased mTORC1-mediated translation of RPIA to bypass senescence in an RB-independent manner. Thus, the mTORC1-RPIA axis is a metabolic vulnerability for p16-null cancers.",
author = "Raquel Buj and Chen, {Chi Wei} and Dahl, {Erika S.} and Leon, {Kelly E.} and Rostislav Kuskovsky and Natella Maglakelidze and Maithili Navaratnarajah and Gao Zhang and Doan, {Mary T.} and Helen Jiang and Michael Zaleski and Lydia Kutzler and Holly Lacko and Yiling Lu and Mills, {Gordon B.} and Raghavendra Gowda and Gavin Robertson and Joshua Warrick and Meenhard Herlyn and Yuka Imamura and Scot Kimball and David Degraff and Snyder, {Nathaniel W.} and Katherine Aird",
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Buj, R, Chen, CW, Dahl, ES, Leon, KE, Kuskovsky, R, Maglakelidze, N, Navaratnarajah, M, Zhang, G, Doan, MT, Jiang, H, Zaleski, M, Kutzler, L, Lacko, H, Lu, Y, Mills, GB, Gowda, R, Robertson, G, Warrick, J, Herlyn, M, Imamura, Y, Kimball, S, Degraff, D, Snyder, NW & Aird, K 2019, 'Suppression of p16 Induces mTORC1-Mediated Nucleotide Metabolic Reprogramming', Cell Reports. https://doi.org/10.1016/j.celrep.2019.07.084

Suppression of p16 Induces mTORC1-Mediated Nucleotide Metabolic Reprogramming. / Buj, Raquel; Chen, Chi Wei; Dahl, Erika S.; Leon, Kelly E.; Kuskovsky, Rostislav; Maglakelidze, Natella; Navaratnarajah, Maithili; Zhang, Gao; Doan, Mary T.; Jiang, Helen; Zaleski, Michael; Kutzler, Lydia; Lacko, Holly; Lu, Yiling; Mills, Gordon B.; Gowda, Raghavendra; Robertson, Gavin; Warrick, Joshua; Herlyn, Meenhard; Imamura, Yuka; Kimball, Scot; Degraff, David; Snyder, Nathaniel W.; Aird, Katherine.

In: Cell Reports, 01.01.2019.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Suppression of p16 Induces mTORC1-Mediated Nucleotide Metabolic Reprogramming

AU - Buj, Raquel

AU - Chen, Chi Wei

AU - Dahl, Erika S.

AU - Leon, Kelly E.

AU - Kuskovsky, Rostislav

AU - Maglakelidze, Natella

AU - Navaratnarajah, Maithili

AU - Zhang, Gao

AU - Doan, Mary T.

AU - Jiang, Helen

AU - Zaleski, Michael

AU - Kutzler, Lydia

AU - Lacko, Holly

AU - Lu, Yiling

AU - Mills, Gordon B.

AU - Gowda, Raghavendra

AU - Robertson, Gavin

AU - Warrick, Joshua

AU - Herlyn, Meenhard

AU - Imamura, Yuka

AU - Kimball, Scot

AU - Degraff, David

AU - Snyder, Nathaniel W.

AU - Aird, Katherine

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Senescence bypass through p16 loss predisposes to transformation and tumorigenesis. Buj et al. found that the loss of p16 upregulates nucleotide metabolism through increased mTORC1-mediated translation of RPIA to bypass senescence in an RB-independent manner. Thus, the mTORC1-RPIA axis is a metabolic vulnerability for p16-null cancers.

AB - Senescence bypass through p16 loss predisposes to transformation and tumorigenesis. Buj et al. found that the loss of p16 upregulates nucleotide metabolism through increased mTORC1-mediated translation of RPIA to bypass senescence in an RB-independent manner. Thus, the mTORC1-RPIA axis is a metabolic vulnerability for p16-null cancers.

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