Surface-to-air suspension behavior of allergen-containing particles in indoor environments

C. Gomes, James Freihaut, William P. Bahnfleth, B. Thran, M. Chapman

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Controlled milling experiments of naturally occurring source materials has led to the establishment of an allergen carrier particle sample bank for common, indoor allergen types from dust mites, roach fras, cat hair and dog fur. Characterization data for allergen specific sample types include: mass fraction and number particle size distributions determined by optical scattering and inertial impactor methods; particle morphology as determined by scanning electron microscope examination; and particle size dependent allergen concentrations determined by immuno-assay enzyme-linked analysis (ELISA). Milling investigations indicate the different parent source materials have very different milling characteristics. Milling conditions must be carefully controlled to give appreciable yields of suspendable particles in the 0.5 - 20 μm size range. Characterized, allergen carrier particles are then utilized in an experimental resuspension apparatus in which controlled vibration and aerodynamic disturbances intensities are applied to known sample dust loadings on specific flooring material types. The experiments lead to particle resuspension rates and factors that are utilized to determine inhalation exposure risks associated with normal, indoor human activity. The resuspension propensities of the allergen carrier particles are compared to quartz "reference" particles and Bacillus Thuringiensis spores of the same size range. Particle resuspension propensities of the allergen particles are mainly dependent on aerodynamic disturbance intensities, with particle and floor types showing second order effects. For the particles investigated, spore particles had the greatest resuspension propensity. The allergen carrier particle samples are also used in exposure challenge chamber studies, to determine quantitative effectiveness of passive and active air filtration systems, and to assess the effectiveness of allergen denaturing techniques for particle embedded allergens.

Original languageEnglish (US)
Title of host publicationProceedings of the A and WMA Indoor Environmental Quality
Subtitle of host publicationProblems, Research and Solutions Conference 2006
Pages582-609
Number of pages28
StatePublished - Dec 1 2006
EventA and WMA Indoor Environmental Quality: Problems, Research and Solutions Conference 2006 - Durham, NC, United States
Duration: Jul 17 2006Jul 19 2006

Publication series

NameProceedings of the A and WMA Indoor Environmental Quality: Problems, Research and Solutions Conference 2006
Volume2

Other

OtherA and WMA Indoor Environmental Quality: Problems, Research and Solutions Conference 2006
CountryUnited States
CityDurham, NC
Period7/17/067/19/06

Fingerprint

Allergens
air
Air
resuspension
Dust
Aerodynamics
indoor environment
allergen
particle
range size
aerodynamics
spore
Bacilli
particle size
dust
Particle size analysis
disturbance
Quartz
Assays
immunoassay

All Science Journal Classification (ASJC) codes

  • Engineering(all)
  • Environmental Science(all)

Cite this

Gomes, C., Freihaut, J., Bahnfleth, W. P., Thran, B., & Chapman, M. (2006). Surface-to-air suspension behavior of allergen-containing particles in indoor environments. In Proceedings of the A and WMA Indoor Environmental Quality: Problems, Research and Solutions Conference 2006 (pp. 582-609). (Proceedings of the A and WMA Indoor Environmental Quality: Problems, Research and Solutions Conference 2006; Vol. 2).
Gomes, C. ; Freihaut, James ; Bahnfleth, William P. ; Thran, B. ; Chapman, M. / Surface-to-air suspension behavior of allergen-containing particles in indoor environments. Proceedings of the A and WMA Indoor Environmental Quality: Problems, Research and Solutions Conference 2006. 2006. pp. 582-609 (Proceedings of the A and WMA Indoor Environmental Quality: Problems, Research and Solutions Conference 2006).
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Gomes, C, Freihaut, J, Bahnfleth, WP, Thran, B & Chapman, M 2006, Surface-to-air suspension behavior of allergen-containing particles in indoor environments. in Proceedings of the A and WMA Indoor Environmental Quality: Problems, Research and Solutions Conference 2006. Proceedings of the A and WMA Indoor Environmental Quality: Problems, Research and Solutions Conference 2006, vol. 2, pp. 582-609, A and WMA Indoor Environmental Quality: Problems, Research and Solutions Conference 2006, Durham, NC, United States, 7/17/06.

Surface-to-air suspension behavior of allergen-containing particles in indoor environments. / Gomes, C.; Freihaut, James; Bahnfleth, William P.; Thran, B.; Chapman, M.

Proceedings of the A and WMA Indoor Environmental Quality: Problems, Research and Solutions Conference 2006. 2006. p. 582-609 (Proceedings of the A and WMA Indoor Environmental Quality: Problems, Research and Solutions Conference 2006; Vol. 2).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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Gomes C, Freihaut J, Bahnfleth WP, Thran B, Chapman M. Surface-to-air suspension behavior of allergen-containing particles in indoor environments. In Proceedings of the A and WMA Indoor Environmental Quality: Problems, Research and Solutions Conference 2006. 2006. p. 582-609. (Proceedings of the A and WMA Indoor Environmental Quality: Problems, Research and Solutions Conference 2006).