TY - JOUR
T1 - Surfactant protein genetic marker alleles identify a subgroup of tuberculosis in a Mexican population
AU - Floros, Joanna
AU - Lin, Hung Mo
AU - Garcia, Andrea
AU - Salazar, Miguel Angel
AU - Guo, Xiaoxuan
AU - DiAngelo, Susan
AU - Montaño, Martha
AU - Luo, Junming
AU - Pardo, Annie
AU - Selman, Moises
N1 - Funding Information:
Financial support: General Clinical Research Center, Pennsylvania State University; National Institutes of Health (HL-34788).
PY - 2000
Y1 - 2000
N2 - Pulmonary surfactant and its components are essential for normal lung function and are involved in local host defense. Surfactant protein (SP)-A and SP-D bind to and modulate phagocytosis of Mycobacteriurn tuberculosis by macrophages. Frequency comparisons of SP marker alleles in tuberculosis patients and healthy control subjects (tuberculin-skin test positive or general population) were performed. Regression analyses of the tuberculosis and the tuberculin-skin test positive groups revealed, on the basis of odds ratios, tuberculosis susceptibility (DA11-C and GATA-3) and protective (AAG-2) marker alleles. Similarly, between tuberculosis patients and general population control subjects, susceptibility 1A3, 6A4, and B1013-A and protective AAGG-1, and AAGG-7 marker alleles were observed. Moreover, interactions were seen between alleles 6A2 and 1A3 (P = .0064) and between 1A3 and B1013-A (P = .036). The findings indicate a possible involvement of SP alleles in tuberculosis pathogenesis.
AB - Pulmonary surfactant and its components are essential for normal lung function and are involved in local host defense. Surfactant protein (SP)-A and SP-D bind to and modulate phagocytosis of Mycobacteriurn tuberculosis by macrophages. Frequency comparisons of SP marker alleles in tuberculosis patients and healthy control subjects (tuberculin-skin test positive or general population) were performed. Regression analyses of the tuberculosis and the tuberculin-skin test positive groups revealed, on the basis of odds ratios, tuberculosis susceptibility (DA11-C and GATA-3) and protective (AAG-2) marker alleles. Similarly, between tuberculosis patients and general population control subjects, susceptibility 1A3, 6A4, and B1013-A and protective AAGG-1, and AAGG-7 marker alleles were observed. Moreover, interactions were seen between alleles 6A2 and 1A3 (P = .0064) and between 1A3 and B1013-A (P = .036). The findings indicate a possible involvement of SP alleles in tuberculosis pathogenesis.
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U2 - 10.1086/315866
DO - 10.1086/315866
M3 - Article
C2 - 11023470
AN - SCOPUS:0033790682
SN - 0022-1899
VL - 182
SP - 1473
EP - 1478
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 5
ER -
