Surfactant protein genetic marker alleles identify a subgroup of tuberculosis in a Mexican population

Joanna Floros, Hung Mo Lin, Andrea Garcia, Miguel Angel Salazar, Xiaoxuan Guo, Susan DiAngelo, Martha Montaño, Junming Luo, Annie Pardo, Moises Selman

Research output: Contribution to journalArticlepeer-review

129 Scopus citations

Abstract

Pulmonary surfactant and its components are essential for normal lung function and are involved in local host defense. Surfactant protein (SP)-A and SP-D bind to and modulate phagocytosis of Mycobacteriurn tuberculosis by macrophages. Frequency comparisons of SP marker alleles in tuberculosis patients and healthy control subjects (tuberculin-skin test positive or general population) were performed. Regression analyses of the tuberculosis and the tuberculin-skin test positive groups revealed, on the basis of odds ratios, tuberculosis susceptibility (DA11-C and GATA-3) and protective (AAG-2) marker alleles. Similarly, between tuberculosis patients and general population control subjects, susceptibility 1A3, 6A4, and B1013-A and protective AAGG-1, and AAGG-7 marker alleles were observed. Moreover, interactions were seen between alleles 6A2 and 1A3 (P = .0064) and between 1A3 and B1013-A (P = .036). The findings indicate a possible involvement of SP alleles in tuberculosis pathogenesis.

Original languageEnglish (US)
Pages (from-to)1473-1478
Number of pages6
JournalJournal of Infectious Diseases
Volume182
Issue number5
DOIs
StatePublished - 2000

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Infectious Diseases

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