Perhaps the most straightforward clinical application of validated regional ventricular mechanics models for diseased hearts is the simulation of a novel surgical procedure or medical device for treating heart failure or ischemic cardiomyopathy. In each study our cardiac biomechanics laboratory uses one of two different approaches: (1) an axisymmetric truncated ellipsoidal model with left ventricular (LV) cavity and wall volumes typical of the failing human heart or animal model of heart failure to determine efficacy of the surgical procedure or device; or (2) an animal-or patient-specific fully 3-D model of the infarcted LV created using echocardiography or MRI to optimize the design of the surgical procedure or device. This chapter is concerned with brief descriptions of the studies from our laboratory that provide the best examples of these two approaches.
|Original language||English (US)|
|Title of host publication||Computational Cardiovascular Mechanics|
|Subtitle of host publication||Modeling and Applications in Heart Failure|
|Number of pages||14|
|State||Published - Dec 1 2010|
All Science Journal Classification (ASJC) codes