Sutureless repair of corneal injuries using naturally derived bioadhesive hydrogels

Ehsan Shirzaei Sani, Ahmad Kheirkhah, Devyesh Rana, Zhongmou Sun, William Foulsham, Amir Sheikhi, Ali Khademhosseini, Reza Dana, Nasim Annabi

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

Corneal injuries are common causes of visual impairment worldwide. Accordingly, there is an unmet need for transparent biomaterials that have high adhesion, cohesion, and regenerative properties. Herein, we engineer a highly biocompatible and transparent bioadhesive for corneal reconstruction using a visible light cross-linkable, naturally derived polymer, GelCORE (gel for corneal regeneration). The physical properties of GelCORE could be finely tuned by changing prepolymer concentration and photocrosslinking time. GelCORE revealed higher tissue adhesion compared to commercial adhesives. Furthermore, in situ photopolymerization of GelCORE facilitated easy delivery to the cornea, allowing for bioadhesive curing precisely according to the required geometry of the defect. In vivo experiments, using a rabbit stromal defect model, showed that bioadhesive could effectively seal corneal defects and induce stromal regeneration and re-epithelialization. Overall, GelCORE has many advantages including low cost and ease of production and use. This makes GelCORE a promising bioadhesive for corneal repair.

Original languageEnglish (US)
Article numbereaav1281
JournalScience Advances
Volume5
Issue number3
DOIs
StatePublished - Jan 1 2019

All Science Journal Classification (ASJC) codes

  • Physics and Astronomy (miscellaneous)
  • General

Fingerprint Dive into the research topics of 'Sutureless repair of corneal injuries using naturally derived bioadhesive hydrogels'. Together they form a unique fingerprint.

  • Cite this

    Sani, E. S., Kheirkhah, A., Rana, D., Sun, Z., Foulsham, W., Sheikhi, A., Khademhosseini, A., Dana, R., & Annabi, N. (2019). Sutureless repair of corneal injuries using naturally derived bioadhesive hydrogels. Science Advances, 5(3), [eaav1281]. https://doi.org/10.1126/sciadv.aav1281