SweepFinder2: Increased sensitivity, robustness and flexibility

Michael Degiorgio, Christian D. Huber, Melissa J. Hubisz, Ines Hellmann, Rasmus Nielsen

Research output: Contribution to journalArticle

46 Scopus citations

Abstract

SweepFinder is a widely used program that implements a powerful likelihood-based method for detecting recent positive selection, or selective sweeps. Here, we present SweepFinder2, an extension of SweepFinder with increased sensitivity and robustness to the confounding effects of mutation rate variation and background selection. Moreover, SweepFinder2 has increased flexibility that enables the user to specify test sites, set the distance between test sites and utilize a recombination map. Contact:

Original languageEnglish (US)
Pages (from-to)1895-1897
Number of pages3
JournalBioinformatics
Volume32
Issue number12
DOIs
StatePublished - Jun 15 2016

All Science Journal Classification (ASJC) codes

  • Statistics and Probability
  • Biochemistry
  • Molecular Biology
  • Computer Science Applications
  • Computational Theory and Mathematics
  • Computational Mathematics

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  • Cite this

    Degiorgio, M., Huber, C. D., Hubisz, M. J., Hellmann, I., & Nielsen, R. (2016). SweepFinder2: Increased sensitivity, robustness and flexibility. Bioinformatics, 32(12), 1895-1897. https://doi.org/10.1093/bioinformatics/btw051