21 Citations (Scopus)

Abstract

Background: Sweet's syndrome (SS), acute febrile neutrophilic dermatosis, has been linked to hematologic malignancies and presents with characteristic edematous dermal plaques. Peripheral blood neutrophilia is frequently seen in association with SS and is one of the diagnostic criteria. Objective: To report the clinical, laboratory, and hematologic data of four patients with myeloid leukemia who developed SS after chemotherapy. Three of these patients were neutropenic. Methods: A retrospective study of four patients with SS and hematologic malignancies was undertaken. Three patients had de novo acute myelogenous leukemia and one was in the acute blast crisis of chronic myelogenous leukemia. Results: Sweet's syndrome was not originally suspected in these patients because of the low peripheral white blood cell counts caused by chemotherapy. All of the patients presented with fevers, arthralgias, and an eruption. They had been treated with antibiotics because of a presumed infection. Once the correct diagnosis was made and oral prednisolone was started, a rapid response followed. Conclusions: Sweet's syndrome should be considered in the differential diagnosis when acute myeloid leukemic patients develop skin lesions and unexplained fevers regardless of the peripheral blood counts.

Original languageEnglish (US)
Pages (from-to)108-112
Number of pages5
JournalInternational Journal of Dermatology
Volume37
Issue number2
DOIs
StatePublished - Feb 1 1998

Fingerprint

Sweet Syndrome
Hematologic Neoplasms
Fever
Blast Crisis
Drug Therapy
Skin
Myeloid Leukemia
Arthralgia
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Prednisolone
Leukocyte Count
Acute Myeloid Leukemia
Differential Diagnosis
Retrospective Studies
Anti-Bacterial Agents
Infection

All Science Journal Classification (ASJC) codes

  • Dermatology

Cite this

Probert, Christine ; Christopher Ehmann, W. ; Al-Mondhiry, Hamid ; Ballard, J. ; Helm, Klaus F. / Sweet's syndrome without granulocytosis. In: International Journal of Dermatology. 1998 ; Vol. 37, No. 2. pp. 108-112.
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title = "Sweet's syndrome without granulocytosis",
abstract = "Background: Sweet's syndrome (SS), acute febrile neutrophilic dermatosis, has been linked to hematologic malignancies and presents with characteristic edematous dermal plaques. Peripheral blood neutrophilia is frequently seen in association with SS and is one of the diagnostic criteria. Objective: To report the clinical, laboratory, and hematologic data of four patients with myeloid leukemia who developed SS after chemotherapy. Three of these patients were neutropenic. Methods: A retrospective study of four patients with SS and hematologic malignancies was undertaken. Three patients had de novo acute myelogenous leukemia and one was in the acute blast crisis of chronic myelogenous leukemia. Results: Sweet's syndrome was not originally suspected in these patients because of the low peripheral white blood cell counts caused by chemotherapy. All of the patients presented with fevers, arthralgias, and an eruption. They had been treated with antibiotics because of a presumed infection. Once the correct diagnosis was made and oral prednisolone was started, a rapid response followed. Conclusions: Sweet's syndrome should be considered in the differential diagnosis when acute myeloid leukemic patients develop skin lesions and unexplained fevers regardless of the peripheral blood counts.",
author = "Christine Probert and {Christopher Ehmann}, W. and Hamid Al-Mondhiry and J. Ballard and Helm, {Klaus F.}",
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Sweet's syndrome without granulocytosis. / Probert, Christine; Christopher Ehmann, W.; Al-Mondhiry, Hamid; Ballard, J.; Helm, Klaus F.

In: International Journal of Dermatology, Vol. 37, No. 2, 01.02.1998, p. 108-112.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Sweet's syndrome without granulocytosis

AU - Probert, Christine

AU - Christopher Ehmann, W.

AU - Al-Mondhiry, Hamid

AU - Ballard, J.

AU - Helm, Klaus F.

PY - 1998/2/1

Y1 - 1998/2/1

N2 - Background: Sweet's syndrome (SS), acute febrile neutrophilic dermatosis, has been linked to hematologic malignancies and presents with characteristic edematous dermal plaques. Peripheral blood neutrophilia is frequently seen in association with SS and is one of the diagnostic criteria. Objective: To report the clinical, laboratory, and hematologic data of four patients with myeloid leukemia who developed SS after chemotherapy. Three of these patients were neutropenic. Methods: A retrospective study of four patients with SS and hematologic malignancies was undertaken. Three patients had de novo acute myelogenous leukemia and one was in the acute blast crisis of chronic myelogenous leukemia. Results: Sweet's syndrome was not originally suspected in these patients because of the low peripheral white blood cell counts caused by chemotherapy. All of the patients presented with fevers, arthralgias, and an eruption. They had been treated with antibiotics because of a presumed infection. Once the correct diagnosis was made and oral prednisolone was started, a rapid response followed. Conclusions: Sweet's syndrome should be considered in the differential diagnosis when acute myeloid leukemic patients develop skin lesions and unexplained fevers regardless of the peripheral blood counts.

AB - Background: Sweet's syndrome (SS), acute febrile neutrophilic dermatosis, has been linked to hematologic malignancies and presents with characteristic edematous dermal plaques. Peripheral blood neutrophilia is frequently seen in association with SS and is one of the diagnostic criteria. Objective: To report the clinical, laboratory, and hematologic data of four patients with myeloid leukemia who developed SS after chemotherapy. Three of these patients were neutropenic. Methods: A retrospective study of four patients with SS and hematologic malignancies was undertaken. Three patients had de novo acute myelogenous leukemia and one was in the acute blast crisis of chronic myelogenous leukemia. Results: Sweet's syndrome was not originally suspected in these patients because of the low peripheral white blood cell counts caused by chemotherapy. All of the patients presented with fevers, arthralgias, and an eruption. They had been treated with antibiotics because of a presumed infection. Once the correct diagnosis was made and oral prednisolone was started, a rapid response followed. Conclusions: Sweet's syndrome should be considered in the differential diagnosis when acute myeloid leukemic patients develop skin lesions and unexplained fevers regardless of the peripheral blood counts.

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