Switching between gamma and theta: Dynamic network control using subthreshold electric fields

Julia Berzhanskaya, Anatoli Gorchetchnikov, Steven Schiff

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

We implemented an experimentally observed orthogonal arrangement of theta and gamma generation circuitry in septotemporal and lamellar dimensions is a two-dimensional model of hippocampus. The model includes three types of cells: pyramidal, basket, and oriens lacunosum-moleculare (OLM) neurons. In this reduced model, application of continuous electric fields allowed us to switch between theta, gamma and mixed theta-gamma regimes without additional pharmacological manipulation. Electric field effects on individual neurons were modeled based on experimental data. Network simulation results predict a flexible experimental technique, which would employ adaptive subthreshold electric fields to continuously modulate neuronal ensemble activity, and can be used for testing cognitive correlates of oscillatory rhythms as well as for suppressing epileptiform activity.

Original languageEnglish (US)
Pages (from-to)2091-2095
Number of pages5
JournalNeurocomputing
Volume70
Issue number10-12
DOIs
StatePublished - Jun 2007

All Science Journal Classification (ASJC) codes

  • Computer Science Applications
  • Cognitive Neuroscience
  • Artificial Intelligence

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